TY  - JOUR
PY  - 2021//
TI  - The promoting effect of traumatic brain injury on the incidence and progression of glioma: a review of clinical and experimental research
JO  - Journal of inflammation research
A1  - Lan, Yu-Long
A1  - Zhu, Yongjian
A1  - Chen, Gao
A1  - Zhang, Jianmin
SP  - 3707
EP  - 3720
VL  - 14
IS  - 
N2  - The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma have been long discussed and still warrant further research. In this review, we have presented an overview of previous cohort studies and case-control studies. We have summarized the roles of microglial cells, macrophages, astrocytes, and stem cells in post-traumatic glioma formation and development, and reviewed various carcinogenic factors involved during traumatic brain injury, especially those reported in experimental studies indicating a relationship with glioma progression. Besides, traumatic brain injury and glioma share several common pathways, including inflammation and oxidative stress; however, the exact mechanism underlying this co-occurrence is yet to be discovered. In this review, we have summarized current epidemiological studies, clinical reports, pathophysiological research, as well as investigations evaluating the probable causes of co-occurrence and treatment possibilities. More efforts should be directed toward elucidating the relationship between traumatic brain injury and glioma, which could likely lead to promising pharmacological interventions towards designing therapeutic strategies.<p />  <p>Language: en</p>
LA  - en
SN  - 1178-7031
UR  - http://dx.doi.org/10.2147/JIR.S325678
ID  - ref1
ER  -