TY  - JOUR
PY  - 2021//
TI  - Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
JO  - Nature neuroscience
A1  - Karlsson Linnér, Richard
A1  - Mallard, Travis T.
A1  - Barr, Peter B.
A1  - Sanchez-Roige, Sandra
A1  - Madole, James W.
A1  - Driver, Morgan N.
A1  - Poore, Holly E.
A1  - de Vlaming, Ronald
A1  - Grotzinger, Andrew D.
A1  - Tielbeek, Jorim J.
A1  - Johnson, Emma C.
A1  - Liu, Mengzhen
A1  - Rosenthal, Sara Brin
A1  - Ideker, Trey
A1  - Zhou, Hang
A1  - Kember, Rachel L.
A1  - Pasman, Joëlle A.
A1  - Verweij, Karin J. H.
A1  - Liu, Dajiang J.
A1  - Vrieze, Scott
A1  - Kranzler, Henry R.
A1  - Gelernter, Joel
A1  - Harris, Kathleen Mullan
A1  - Tucker-Drob, Elliot M.
A1  - Waldman, Irwin D.
A1  - Palmer, Abraham A.
A1  - Harden, K. Paige
A1  - Koellinger, Philipp D.
A1  - Dick, Danielle M.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for genes expressed in the brain and related to nervous system development. A polygenic score constructed from our results predicts a range of behavioral and medical outcomes that were not part of genome-wide analyses, including traits that until now lacked well-performing polygenic scores, such as opioid use disorder, suicide, HIV infections, criminal convictions and unemployment. Our findings are consistent with the idea that persistent difficulties in self-regulation can be conceptualized as a neurodevelopmental trait with complex and far-reaching social and health correlates.<p />  <p>Language: en</p>
LA  - en
SN  - 1097-6256
UR  - http://dx.doi.org/10.1038/s41593-021-00908-3
ID  - ref1
ER  -