TY  - JOUR
PY  - 2021//
TI  - Head injury is associated with tau deposition on PET in MCI and AD patients
JO  - Alzheimer's and dementia: diagnosis, assessment and disease monitoring
A1  - Jagust, William J.
A1  - Wu, Yu-Chien
A1  - Deardorff, Rachael
A1  - West, John D.
A1  - Risacher, Shannon L.
A1  - McAllister, Thomas W.
A1  - Apostolova, Liana G.
A1  - Saykin, Andrew J.
A1  - Weiner, Michael W.
A1  - Landau, Susan M.
A1  - Brosch, Jared R.
A1  - Farlow, Martin R.
A1  - Gao, Sujuan
SP  - e12230
EP  - e12230
VL  - 13
IS  - 1
N2  - INTRODUCTION: Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. <br><br>METHODS: Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cognitive impairment (CN, n = 450) with amyloid and [(18)F]flortaucipir positron emission tomography, HI history information, and cognitive testing from the Alzheimer's Disease Neuroimaging Initiative and the Indiana Memory and Aging Study. <br><br>RESULTS: Sixty-three (38 CN, 25 impaired) reported a history of HI. Higher neuropsychiatric scores and poorer memory were observed in those with a history of HI. Tau was higher in individuals with a history of HI, especially those who experienced a loss of consciousness (LOC). <br><br>RESULTS were driven by impaired individuals, especially amyloid beta-positive individuals with history of HI with LOC. <br><br>DISCUSSION: These findings suggest biological changes, such as greater tau, are associated with HI in individuals with cognitive impairment. Small effect sizes were observed; thus, further studies should replicate and extend these results.<p />  <p>Language: en</p>
LA  - en
SN  - 2352-8729
UR  - http://dx.doi.org/10.1002/dad2.12230
ID  - ref1
ER  -