TY  - JOUR
PY  - 2021//
TI  - Investigation of tissue level tolerance for cerebral contusion in a controlled cortical impact porcine model
JO  - Traffic injury prevention
A1  - De Kegel, Dries
A1  - Musigazi, Gracia Umuhire
A1  - Menichetti, Andrea
A1  - Hellings, Peter-William
A1  - Sciot, Raf
A1  - Demaerel, Philippe
A1  - Famaey, Nele
A1  - Vander Sloten, Jos
A1  - Depreitere, Bart
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Cerebral contusions (CC) represent a frequent lesion in traumatic brain injury, with potential morbidity from mass effect and tissue loss. Better understanding of the mechanical etiology will help to improve head protection. The goal of this study is to investigate the threshold for mechanical impact parameters to induce CC in an in vivo porcine controlled cortical impact model. <br><br>METHODS: Thirty-four adult male pigs underwent craniotomy and controlled cortical impact with a hemispherical tip on intact dura under general anesthesia. Peak impact depth varied between 1.1 and 12.6 mm, and impact velocity between 0.4 and 2.2 m/s while the dwell time was kept at 200 ms. Two days following impact, the animals underwent magnetic resonance (MR) imaging of the brain, and were subsequently sacrificed for brain extraction. CC damage was investigated by magnetic resonance imaging and histology. <br><br>RESULTS: All animals recovered from the impact without overt neurological deficit. Provoked injuries were histologically confirmed to be CC. Decreasing probability of cortical damage and white matter edema volume was observed with decreasing impact depth and velocity. No CC could be demonstrated below a product of impact depth and velocity of 0.8 mm*m/s, whereas the probability for CC was one third below 15 mm*m/s. The threshold for CC development as estimated from the current series of experiments, was situated at an impact depth of 2.0 mm and impact velocity of 0.4 m/s. <br><br>CONCLUSION: Mechanical thresholds for CC development could be explored in the current porcine controlled cortical impact model. <br><br>FINDINGS will be used to further refine a cerebral contusion porcine model with volumetric histology data in light of future finite element cerebral contusion validation studies.<p />  <p>Language: en</p>
LA  - en
SN  - 1538-9588
UR  - http://dx.doi.org/10.1080/15389588.2021.1957856
ID  - ref1
ER  -