TY  - JOUR
PY  - 2021//
TI  - Retrospective observational study of daytime add-on administration of zopiclone to difficult-to-treat psychiatric inpatients with unpredictable aggressive behavior, with or without EEG dysrhythmia
JO  - Frontiers in psychiatry
A1  - Ceccherini-Nelli, Alfonso
A1  - Bucuci, Elena
A1  - Burback, Lisa
A1  - Li, Daniel
A1  - Alikouzehgaran, Maryam
A1  - Latif, Zahid
A1  - Morin, Kevin
A1  - Ganapathy, Karthikeyan
A1  - Salsali, Manhaz
A1  - Abdullah, Ubaid
A1  - Westwood, Wanda
A1  - Orris, Janice
A1  - White, Patrick J.
SP  - e693788
EP  - e693788
VL  - 12
IS  - 
N2  - Managing violent behavior is a particularly challenging aspect of hospital psychiatric care. Available pharmacological interventions are often unsatisfactory. <br><br>AIM: To assess the effectiveness and safety of daytime zopiclone add-on administration in violent and difficult-to-treat psychiatric inpatients. <br><br>METHODS: Chart review of inpatients treated with daytime zopiclone, between 2014 and 2018, with up to 12 weeks follow-up. Effectiveness was retrospectively assessed with the Clinical Global Impression rating scale (CGI) and the frequency and severity of aggressive incidents recorded with the Staff Observation Aggression Scale-Revised (SOAS-R). <br><br>RESULTS: Forty-five (30 male, 15 female) cases, 18-69 years age range, average (SD) baseline CGI-S score of 5.4 (1.0), and a variety of diagnoses. Sixty-nine percent showed CGI-S improvement of any degree. For patients with at least one aggressive incident within 7 days prior to initiation of zopiclone (N = 22), average (SD) SOAS-R-Severity LOCF to baseline change was -3.5 (2.7) P < 0.0001. Most patients reported no side effects; 24% reported one or more side effects, and 11% discontinued zopiclone due to sedation (4), insomnia (1) or slurred speech (1). No SAEs were recorded. Zopiclone maximum daily dose correlated with CGI-S baseline-to-LOCF change (rho = -0.5, P = 0.0003). The ROC AUC of zopiclone maximum daily dose and improvement on CGI-S was 0.84 (95% CI 0.70-0.93, P < 0.0001). The ROC AUC of zopiclone maximum daily dose and SOAS-R-N improvement was 0.80 (95% CI 0.58-0.92; P = 0.0008) and maximum Youden's index value was achieved at a dose of >30 mg. <br><br>CONCLUSIONS: Zopiclone doses >30 mg daily achieved the best anti-aggressive effect.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-0640
UR  - http://dx.doi.org/10.3389/fpsyt.2021.693788
ID  - ref1
ER  -