TY  - JOUR
PY  - 2021//
TI  - Approach-avoidance tendencies in depression and childhood trauma: no effect of noradrenergic stimulation
JO  - Comprehensive psychoneuroendocrinology
A1  - Deuter, Christian Eric
A1  - Smit, Janna
A1  - Kaczmarczyk, Michael
A1  - Wingenfeld, Katja
A1  - Otte, Christian
A1  - Kuehl, Linn Kristina
SP  - e100077
EP  - e100077
VL  - 8
IS  - 
N2  - Adverse childhood experiences (ACE) are a major risk factor for major depressive disorder (MDD) in later life. Both conditions are characterized by dysregulations in the noradrenergic system related which again could represent a mediating mechanism for deficits in affective processing and behavioral functioning. In this double-blind, placebo-controlled study we tested the hypothesis that ACE and MDD are characterized by aberrant approach-avoidance (AA) tendencies and that these are mitigated after noradrenergic stimulation with yohimbine. In a mixed-measures, fully crossed design, participants (N = 131, 73 women) with/without MDD and with/without ACE received a single-dose of yohimbine or placebo on different days, followed by an AA task. We found modulation of AA tendencies by the emotional valence of target images, yet there were no effects of group or treatment. From these results, we conclude that AA tendencies are not critically affected by MDD or ACE and that the noradrenergic system is not substantially involved in this behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 2666-4976
UR  - http://dx.doi.org/10.1016/j.cpnec.2021.100077
ID  - ref1
ER  -