TY  - JOUR
PY  - 2021//
TI  - Interaction of cognitive decline and walking ability to influence wandering behavior: a cohort study [conference abstract]
JO  - International journal of epidemiology
A1  - Murata, Shunsuke
A1  - Takegami, Misa
A1  - Ogata, Soshiro
A1  - Ono, Rei
A1  - Nakaoku, Yuriko
A1  - Hagihara, Akihito
A1  - Nishimura, Kunihiro
SP  - dyab168.465
EP  - dyab168.465
VL  - 50
IS  - Suppl 1
N2  - IEA World Congress of Epidemiology 2021 - Scientific Program Abstracts            Background      Wandering behavior is one of the most troublesome behavioral disturbances in dementia. Though cognitive decline leads to wandering behavior, its effects may vary across walking ability. The purpose of this study was to investigate the joint effect of cognitive decline and walking ability on wandering behavior.                 Methods      This retrospective cohort study in community analyzed 3920 elderly adults with dementia. The association of cognitive function and walking ability with an incidence of wandering behavior during a 5-year follow-up period were examined using a generalized linear model, and relative excess risk due to interaction was calculated.                 Results      Compared to 'walk independently', adjusted risk ratios (95% confidence intervals) for 'walk with help' and 'unable to walk' were 0.51 (0.42, 0.63) and 0.21 (0.16, 0.28), respectively (P for trend < 0.001). Compared to mild cognitive decline, adjusted risk ratios (95% confidence intervals) for moderate and severe cognitive decline were 1.44 (1.17, 1.77) and 1.73 (1.36, 2.18), respectively (P for trend < 0.001). Additionally, some joint effects of cognitive decline and walking ability decline were lower than the sum of its individual effects (relative excess risk due to interaction (95% confidence interval), moderate cognitive decline × 'walk with help': -0.45 (-0.98, -0.01); severe cognitive decline × 'unable to walk': -0.95 (-1.71, -0.37)).                 Conclusions      Effects of cognitive decline and walking ability on incidence of wandering behavior were observed, and the effects varied depending on their combination.                 Key messages      Our results help clinicians to predict and manage wandering behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0300-5771
UR  - http://dx.doi.org/10.1093/ije/dyab168.465
ID  - ref1
ER  -