TY  - JOUR
PY  - 2021//
TI  - The effect of aerobic exercise on concussion recovery: a pilot clinical trial
JO  - Journal of the International Neuropsychological Society
A1  - Snyder, Aliyah R.
A1  - Greif, Sarah M.
A1  - Clugston, James R.
A1  - FitzGerald, David B.
A1  - Yarrow, Joshua F.
A1  - Babikian, Talin
A1  - Giza, Christopher C.
A1  - Thompson, Floyd J.
A1  - Bauer, Russell M.
SP  - 790
EP  - 804
VL  - 27
IS  - 8
N2  - OBJECTIVE: The purpose of this study was to pilot safety and tolerability of a 1-week aerobic exercise program during the post-acute phase of concussion (14-25 days post-injury) by examining adherence, symptom response, and key functional outcomes (e.g., cognition, mood, sleep, postural stability, and neurocognitive performance) in young adults. <br><br>METHOD: A randomized, non-blinded pilot clinical trial was performed to compare the effects of aerobic versus non-aerobic exercise (placebo) in concussion patients. The study enrolled three groups: 1) patients with concussion/mild traumatic brain injury (mTBI) randomized to an aerobic exercise intervention performed daily for 1-week, 2) patients with concussion/mTBI randomized to a non-aerobic (stretching and calisthenics) exercise program performed daily for 1-week, and 3) non-injured, no intervention reference group. <br><br>RESULTS: Mixed-model analysis of variance results indicated a significant decrease in symptom severity scores from pre- to post-intervention (mean difference = -7.44, 95% CI [-12.37, -2.20]) for both concussion groups. However, the pre- to post-change was not different between groups. Secondary outcomes all showed improvements by post-intervention, but no differences in trajectory between the groups. By three months post-injury, all outcomes in the concussion groups were within ranges of the non-injured reference group. <br><br>CONCLUSIONS: Results from this study indicate that the feasibility and tolerability of administering aerobic exercise via stationary cycling in the post-acute time frame following post-concussion (14-25 days) period are tentatively favorable. Aerobic exercise does not appear to negatively impact recovery trajectories of neurobehavioral outcomes; however, tolerability may be poorer for patients with high symptom burden.<p />  <p>Language: en</p>
LA  - en
SN  - 1355-6177
UR  - http://dx.doi.org/10.1017/S1355617721000886
ID  - ref1
ER  -