TY  - JOUR
PY  - 2021//
TI  - ICU-admission hyperphosphataemia is related to shock and tissue damage, indicating injury severity and mortality in polytrauma patients
JO  - Diagnostics (Basel, Switzerland)
A1  - Rugg, Christopher
A1  - Bachler, Mirjam
A1  - Kammerlander, Robert
A1  - Niederbrunner, Daniel
A1  - Bösch, Johannes
A1  - Schmid, Stefan
A1  - Kreutziger, Janett
A1  - Ströhle, Mathias
SP  - e1518
EP  - e1518
VL  - 11
IS  - 9
N2  - Hyperphosphataemia can originate from tissue ischaemia and damage and may be associated with injury severity in polytrauma patients. In this retrospective, single-centre study, 166 polytrauma patients (injury severity score (ISS) ≥ 16) primarily requiring intensive care unit (ICU) treatment were analysed within a five-year timeframe. ICU-admission phosphate levels defined a hyperphosphataemic (>1.45 mmol/L; n = 56) opposed to a non-hyperphosphataemic group (n = 110). In the hyperphosphataemic group, injury severity was increased (ISS median and IQR: 38 (30-44) vs. 26 (22-34); p < 0.001), as were signs of shock (lactate, resuscitation requirements), tissue damage (ASAT, ALAT, creatinine) and lastly in-hospital mortality (35.7% vs. 5.5%; p < 0.001). Hyperphosphataemia at ICU admission was shown to be a risk factor for mortality (1.46-2.10 mmol/L: odds ratio (OR) 3.96 (95% confidence interval (CI) 1.03-15.16); p = 0.045; >2.10 mmol/L: OR 12.81 (CI 3.45-47.48); p < 0.001) and admission phosphate levels alone performed as good as injury severity score (ISS) in predicting in-hospital mortality (area under the ROC curve: 0.811 vs. 0.770; p = 0.389). Hyperphosphataemia at ICU admission is related to tissue damage and shock and indicates injury severity and subsequent mortality in polytrauma patients. Admission phosphate levels represent an easily feasible yet strong predictor for in-hospital mortality.<p />  <p>Language: en</p>
LA  - en
SN  - 2075-4418
UR  - http://dx.doi.org/10.3390/diagnostics11091548
ID  - ref1
ER  -