TY  - JOUR
PY  - 2021//
TI  - Violence-related distress and lung function in two longitudinal studies of youth
JO  - European respiratory journal
A1  - Gaietto, Kristina
A1  - Han, Yueh-Ying
A1  - Forno, Erick
A1  - Bacharier, Leonard B.
A1  - Phipatanakul, Wanda
A1  - Guilbert, Theresa W.
A1  - Cabana, Michael D.
A1  - Ross, Kristie
A1  - Blatter, Joshua
A1  - Acosta-Pérez, Edna
A1  - Miller, Gregory E.
A1  - de la Hoz, Rafael E.
A1  - Rosser, Franziska J.
A1  - Durrani, Sandy
A1  - Canino, Glorisa
A1  - Wisniewski, Stephen R.
A1  - Celedon, Juan C.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Increasing violence-related distress over time was associated with worse lung function and worse asthma-related quality of life in youth with asthma despite treatment with low-dose inhaled corticosteroids.Exposure to violence has been associated with lower lung function in cross-sectional studies. We examined whether increasing violence-related distress over time is associated with worse lung function and worse asthma control or quality of life in a secondary analysis of a 48-week randomized clinical trial in 98 youth with asthma (ages 9-16 years) treated with low-dose inhaled corticosteroids (the Vitamin D Kids Asthma Study [VDKA]). We then replicated our findings for lung function in a prospective study of 232 Puerto Rican youth followed for an average of 5·4 years. Violence-related distress was assessed using the Checklist of Children's Distress Symptoms (CCDS) scale. Our outcomes of interest were percent predicted (%pred) lung function measures and (in VDKA only) asthma control (assessed using the Asthma Control Test) and asthma-related quality of life (assessed using the Pediatric Asthma Quality of Life questionnaire). In a multivariable analysis in VDKA, each 1-point increment in the CCDS score was associated with decrements of 3.27% in %predFEV(1) (95% confidence interval [CI]=-6.44% to -0.22%, p=0.04) and a 2.65% decrement in percent predicted FVC (95% CI=-4.86% to -0.45%, p=0.02), and 0.30 points in the overall PAQLQ score (95% CI=-0.50 to -0.10, p<0.01). Similar findings for FEV(1) and FVC were obtained in the prospective study of Puerto Rican youth. Our findings suggest that violence-related distress may worsen lung function and quality of life in youth with asthma (even those treated with low-dose inhaled corticosteroids) and further support policies to reduce exposure to violence among children in the U.S. and Puerto Rico.<p />  <p>Language: en</p>
LA  - en
SN  - 0903-1936
UR  - http://dx.doi.org/10.1183/13993003.02329-2021
ID  - ref1
ER  -