TY - JOUR PY - 2021// TI - Health-related quality of life (HRQoL) outcomes following injury in childhood and adolescence using EuroQol (EQ-5D) responses with pooled longitudinal data JO - International journal of environmental research and public health A1 - Dipnall, Joanna F. A1 - Rivara, Frederick P. A1 - Lyons, Ronan A. A1 - Ameratunga, Shanthi A1 - Brussoni, Mariana A1 - Lecky, Fiona E. A1 - Bradley, Clare A1 - Beck, Ben A1 - Lyons, Jane A1 - Schneeberg, Amy A1 - Harrison, James E. A1 - Gabbe, Belinda J. SP - e10156 EP - e10156 VL - 18 IS - 19 N2 - BACKGROUND: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)-yet valid estimates of burden are absent.

METHODS: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5-17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)).

RESULTS: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (-0.04, 95%CI -0.05, -0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected.

CONCLUSIONS: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.

Language: en

LA - en SN - 1661-7827 UR - http://dx.doi.org/10.3390/ijerph181910156 ID - ref1 ER -