TY  - JOUR
PY  - 2021//
TI  - Factors associated with lifetime suicide attempts in bipolar disorder: results from an Italian nationwide study
JO  - European archives of psychiatry and clinical neuroscience
A1  - Buoli, Massimiliano
A1  - Cesana, Bruno Mario
A1  - Bolognesi, Simone
A1  - Fagiolini, Andrea
A1  - Albert, Umberto
A1  - Di Salvo, Gabriele
A1  - Maina, Giuseppe
A1  - de Bartolomeis, Andrea
A1  - Pompili, Maurizio
A1  - Palumbo, Claudia
A1  - Bondi, Emi
A1  - Steardo, Luca Jr
A1  - De Fazio, Pasquale
A1  - Amore, Mario
A1  - Altamura, Mario
A1  - Bellomo, Antonello
A1  - Bertolino, Alessandro
A1  - Di Nicola, Marco
A1  - Di Sciascio, Guido
A1  - Fiorillo, Andrea
A1  - Sacchetti, Emilio
A1  - Sani, Gabriele
A1  - Siracusano, Alberto
A1  - Di Lorenzo, Giorgio
A1  - Tortorella, Alfonso
A1  - Altamura, A. Carlo
A1  - Dell'osso, Bernardo
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The purpose of the present study was to detect demographic and clinical factors associated with lifetime suicide attempts in Bipolar Disorder (BD). A total of 1673 bipolar patients from different psychiatric departments were compared according to the lifetime presence of suicide attempts on demographic/clinical variables. Owing to the large number of variables statistically related to the dependent variable (presence of suicide attempts) at the univariate analyses, preliminary multiple logistic regression analyses were realized. A final multivariable logistic regression was then performed, considering the presence of lifetime suicide attempts as the dependent variable and statistically significant demographic/clinical characteristics as independent variables. The final multivariable logistic regression analysis showed that an earlier age at first contact with psychiatric services (odds ratio [OR] = 0.97, p < 0.01), the presence of psychotic symptoms (OR = 1.56, p < 0.01) or hospitalizations (OR = 1.73, p < 0.01) in the last year, the attribution of symptoms to a psychiatric disorder (no versus yes: OR = 0.71, partly versus yes OR = 0.60, p < 0.01), and the administration of psychoeducation in the last year (OR = 1.49, p < 0.01) were all factors associated with lifetime suicide attempts in patients affected by BD. In addition, female patients resulted to have an increased association with life-long suicidal behavior compared to males (OR: 1.02, p < 0.01). Several clinical factors showed complex associations with lifetime suicide attempts in bipolar patients. These patients, therefore, require strict clinical monitoring for their predisposition to a less symptom stabilization. Future research will have to investigate the best management strategies to improve the prognosis of bipolar subjects presenting suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0940-1334
UR  - http://dx.doi.org/10.1007/s00406-021-01343-y
ID  - ref1
ER  -