TY  - JOUR
PY  - 2021//
TI  - Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes
JO  - NPJ digital medicine
A1  - Polhemus, Ashley
A1  - Ortiz, Laura Delgado
A1  - Brittain, Gavin
A1  - Chynkiamis, Nikolaos
A1  - Salis, Francesca
A1  - Gaßner, Heiko
A1  - Gross, Michaela
A1  - Kirk, Cameron
A1  - Rossanigo, Rachele
A1  - Taraldsen, Kristin
A1  - Balta, Diletta
A1  - Breuls, Sofie
A1  - Buttery, Sara
A1  - Cardenas, Gabriela
A1  - Endress, Christoph
A1  - Gugenhan, Julia
A1  - Keogh, Alison
A1  - Kluge, Felix
A1  - Koch, Sarah
A1  - Micó-Amigo, M. Encarna
A1  - Nerz, Corinna
A1  - Sieber, Chloé
A1  - Williams, Parris
A1  - Bergquist, Ronny
A1  - de Basea, Magda Bosch
A1  - Buckley, Ellen
A1  - Hansen, Clint
A1  - Mikolaizak, A. Stefanie
A1  - Schwickert, Lars
A1  - Scott, Kirsty
A1  - Stallforth, Sabine
A1  - van Uem, Janet
A1  - Vereijken, Beatrix
A1  - Cereatti, Andrea
A1  - Demeyer, Heleen
A1  - Hopkinson, Nicholas
A1  - Maetzler, Walter
A1  - Troosters, Thierry
A1  - Vogiatzis, Ioannis
A1  - Yarnall, Alison
A1  - Becker, Clemens
A1  - Garcia-Aymerich, Judith
A1  - Leocani, Letizia
A1  - Mazzà, Claudia
A1  - Rochester, Lynn
A1  - Sharrack, Basil
A1  - Frei, Anja
A1  - Puhan, Milo
SP  - e149
EP  - e149
VL  - 4
IS  - 1
N2  - Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice.<p />  <p>Language: en</p>
LA  - en
SN  - 2398-6352
UR  - http://dx.doi.org/10.1038/s41746-021-00513-5
ID  - ref1
ER  -