TY  - JOUR
PY  - 2021//
TI  - Altered hypothalamic functional connectivity following total sleep deprivation in young adult males
JO  - Frontiers in neuroscience
A1  - Qi, Jing
A1  - Li, Bo-Zhi
A1  - Zhang, Ying
A1  - Pan, Bei
A1  - Gao, Yu-Hong
A1  - Zhan, Hao
A1  - Liu, Yong
A1  - Shao, Yong-Cong
A1  - Zhang, Xi
SP  - e688247
EP  - e688247
VL  - 15
IS  - 
N2  - BACKGROUND: Sleep deprivation can markedly influence vigilant attention that is essential to complex cognitive processes. The hypothalamus plays a critical role in arousal and attention regulation. However, the functional involvement of the hypothalamus in attentional impairments after total sleep deprivation (TSD) remains unclear. The purpose of this study is to investigate the alterations in hypothalamic functional connectivity and its association with the attentional performance following TSD. <br><br>METHODS: Thirty healthy adult males were recruited in the study. Participants underwent two resting-state functional magnetic resonance imaging (rs-fMRI) scans, once in rested wakefulness (RW) and once after 36 h of TSD. Seed-based functional connectivity analysis was performed using rs-fMRI for the left and right hypothalamus. Vigilant attention was measured using a psychomotor vigilance test (PVT). Furthermore, Pearson correlation analysis was conducted to investigate the relationship between altered hypothalamic functional connectivity and PVT performance after TSD. <br><br>RESULTS: After TSD, enhanced functional connectivity was observed between the left hypothalamus and bilateral thalamus, bilateral anterior cingulate cortex, right amygdala, and right insula, while reduced functional connectivity was observed between the left hypothalamus and bilateral middle frontal gyrus (AlphaSim corrected, P < 0.01). However, significant correlation between altered hypothalamic functional connectivity and PVT performance was not observed after Bonferroni correction (P > 0.05). <br><br>CONCLUSION: Our results suggest that TSD can lead to disrupted hypothalamic circuits, which may provide new insight into neural mechanisms of attention impairments following sleep deprivation.<p />  <p>Language: en</p>
LA  - en
SN  - 1662-4548
UR  - http://dx.doi.org/10.3389/fnins.2021.688247
ID  - ref1
ER  -