TY  - JOUR
PY  - 2021//
TI  - Inflammation biomarkers in suicide attempts and their relation to abuse, global functioning and cognition
JO  - World journal of biological psychiatry
A1  - Fernández-Sevillano, Jessica
A1  - Gonzalez-Ortega, Itxaso
A1  - MacDowell, Karina
A1  - Zorrilla, Iñaki
A1  - López, María Purificación
A1  - Courtet, Philippe
A1  - Gabilondo, Andrea
A1  - Martinez-Cengotitabengoa, Mónica
A1  - Leza, Juan Carlos
A1  - Saiz, Pilar
A1  - Gonzalez-Pinto, Ana
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVES: To explore the link between cytokines and suicide attempts and their relationship with the psychological aspects of this complex multifactorial phenomenon. <br><br>METHODS: 96 participants, including 20 patients with a recent suicide attempt and diagnosis of Major Depression Disorder (MDD), 33 MDD patients with a lifetime history of suicide attempt, 23 non-attempter MDD patients, and 20 healthy controls underwent an assessment on depressive symptoms, global functioning, aggressive behaviour, presence of abuse and attention performance. Additionally, all participants had a blood extraction for IL-2, IL2-R, IL-4, IL-6, and TNF-α plasma levels analysis. <br><br>RESULTS: IL-6 levels were significantly different across groups (F(3,89)=3.690; p = 0.015), with higher concentrations in both recent (p = 0.04) and distant (p = 0.015) attempt in comparison to MDD non-attempters. IL-6 was associated with adult physical abuse (B = 2.591; p = 0.021), lower global functioning score (B = -0.512; p = 0.011), and poorer performance on attention (B = -0.897; p = 0.011). <br><br>CONCLUSIONS: Recent and distant suicidal behaviour is associated with elevated IL-6 levels, which may be influenced by stressful and traumatic experiences. Elevated concentrations of IL-6 could have a negative impact on attention, increasing suicide risk. More research is needed to clarify the role of cytokines in suicide-related features to explore novel treatments and more effective preventive interventions.<p />  <p>Language: en</p>
LA  - en
SN  - 1562-2975
UR  - http://dx.doi.org/10.1080/15622975.2021.1988703
ID  - ref1
ER  -