TY  - JOUR
PY  - 2021//
TI  - High-frequency repetitive transcranial magnetic stimulation (rTMS) accelerates onset time of beneficial treating effects and improves clinical symptoms of depression
JO  - CNS and neurological disorders drug targets
A1  - Dai, Lilei
A1  - Wang, Peng
A1  - Du, Hui
A1  - Guo, Qingshan
A1  - Li, Fen
A1  - He, Xinfu
A1  - Zou, Shaohong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: In recent years, more and more patients with depression demonstrate suicidal intention and suicidal behavior. <br><br>OBJECTIVE: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating depression with suicidal ideation. <br><br>METHODS: Eighty-nine depression patients with suicide intention were administrated drugs combined with four weeks of Active rTMS (n=40) or sham (n=49) rTMS treatment. The 24-item Hamilton Depression Rating Scale for Depression (HAMD-24) and Self-rating Idea of Suicide Scale (SIOSS) were used to evaluate suicide risk and depression severity at baseline, weeks 2 and 4. A 25% reduction in HAMD-24 score from baseline was defined as treatment response. More than a 20% reduction in HAMD-24 score from baseline within the first 2 weeks of treatment was defined as an early improvement. <br><br>RESULTS: No statistical significance was found for baseline sociodemographic and illness characteristics between the two groups (P >0.05). There was a significant difference for HAMD-24 and SIOSS scores between the two groups at weeks 2 and 4. Active rTMS group demonstrated a more significant score reduction compared to the Sham rTMS group at weeks 2 and 4. There was a significantly greater number of patients with early improvement observed in the Active rTMS group compared to those in the Sham rTMS group at weeks 2 (P <0.05). There was a significant difference in responder rates between the two groups at weeks 4 for HAMD-24 scores (P <0.05). <br><br>CONCLUSION: rTMS could accelerate the onset time of beneficial treating effects and improve clinical symptoms of depression. During the treatment course, cognitive disorder, sleep disorder, anxiety/somatization, retardation, and hopelessness symptoms were improved dramatically, and suicidal ideation was reduced.<p />  <p>Language: en</p>
LA  - en
SN  - 1871-5273
UR  - http://dx.doi.org/10.2174/1871527320666211104123343
ID  - ref1
ER  -