TY  - JOUR
PY  - 2021//
TI  - Opioid use as a proximal risk factor for suicidal behavior in young adults
JO  - Suicide and life-threatening behavior
A1  - Marengo, Laura
A1  - Douaihy, Antoine
A1  - Zhong, Yongqi
A1  - Krancevich, Katie
A1  - Brummit, Bradley
A1  - Sakolsky, Dara
A1  - Deal, Meredith
A1  - Zelazny, Jamie
A1  - Goodfriend, Eli
A1  - Saul, Melissa
A1  - Murata, Stephen
A1  - Thoma, Brian
A1  - Mansour, Hader
A1  - Tew, Jamie
A1  - Ahmed, Nadeem
A1  - Marsland, Anna
A1  - Brent, David
A1  - Melhem, Nadine M.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: There is a concomitant rise in suicide rates with the prevalence of opioids involved in overdose deaths, especially among adolescents and young adults. However, there are limited studies on whether opioid use prospectively predicts suicidal behavior in youth. <br><br>METHODS: Our sample included 183 psychiatric patients (18-30 years) admitted for a suicide attempt (SA), have current suicidal ideation (SI), and psychiatric controls without ideation or attempt (PC). Suicidal behavior was assessed using the Columbia Suicide Severity Rating Scale. We also recruited a healthy control group (HC; n = 40). Patients and controls were followed over a year. ANOVA, regression, and cox regression were used. <br><br>RESULTS: Suicide attempt (β = 0.87, CI [0.1-1.6], p = 0.02) and SI [(β = 0.75, CI [0.03-1.5], p = 0.04) were significantly more likely than HCs to have used opioids in the past year at baseline. Opioid use was associated with increased anxiety symptoms (β = 0.75, CI [0.001-1.5], p = 0.05), PTSD symptoms (β = 3.90, CI [1.1-6.7], p = 0.01), and aggression (β = 0.02, CI [0.01-0.04], p = 0.02). Opioid use in the month prior to hospitalization predicted SA at 6 months (OR = 1.87, CI [1.06-3.31], p = 0.032). <br><br>CONCLUSIONS: Opioid use is a proximal predictor for SA. These findings may help clinicians better identify patients at risk for suicidal behavior, allowing for more personalized treatment approaches.<p />  <p>Language: en</p>
LA  - en
SN  - 0363-0234
UR  - http://dx.doi.org/10.1111/sltb.12806
ID  - ref1
ER  -