TY  - JOUR
PY  - 2021//
TI  - Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women
JO  - Science advances
A1  - Mishor, Eva
A1  - Amir, Daniel
A1  - Weiss, Tali
A1  - Honigstein, Danielle
A1  - Weissbrod, Aharon
A1  - Livne, Ethan
A1  - Gorodisky, Lior
A1  - Karagach, Shiri
A1  - Ravia, Aharon
A1  - Snitz, Kobi
A1  - Karawani, Diyala
A1  - Zirler, Rotem
A1  - Weissgross, Reut
A1  - Soroka, Timna
A1  - Endevelt-Shapira, Yaara
A1  - Agron, Shani
A1  - Rozenkrantz, Liron
A1  - Reshef, Netta
A1  - Furman-Haran, Edna
A1  - Breer, Heinz
A1  - Strotmann, Joerg
A1  - Uebi, Tatsuya
A1  - Ozaki, Mamiko
A1  - Sobel, Noam
SP  - eabg1530
EP  - eabg1530
VL  - 7
IS  - 47
N2  - In terrestrial mammals, body volatiles can effectively trigger or block conspecific aggression. Here, we tested whether hexadecanal (HEX), a human body volatile implicated as a mammalian-wide social chemosignal, affects human aggression. Using validated behavioral paradigms, we observed a marked dissociation: Sniffing HEX blocked aggression in men but triggered aggression in women. Next, using functional brain imaging, we uncovered a pattern of brain activity mirroring behavior: In both men and women, HEX increased activity in the left angular gyrus, an area implicated in perception of social cues. HEX then modulated functional connectivity between the angular gyrus and a brain network implicated in social appraisal (temporal pole) and aggressive execution (amygdala and orbitofrontal cortex) in a sex-dependent manner consistent with behavior: increasing connectivity in men but decreasing connectivity in women. These findings implicate sex-specific social chemosignaling at the mechanistic heart of human aggressive behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 2375-2548
UR  - http://dx.doi.org/10.1126/sciadv.abg1530
ID  - ref1
ER  -