TY  - JOUR
PY  - 2021//
TI  - Frailty and falls in people living with multiple sclerosis
JO  - Archives of physical medicine and rehabilitation
A1  - Zanotto, Tobia
A1  - Galperin, Irina
A1  - Mirelman, Anat
A1  - Yehezkiyahu, Shahar
A1  - Estes, John
A1  - Chen, Lingjun
A1  - Regev, Keren
A1  - Karni, Arnon
A1  - Schmitz-Hübsch, Tanja
A1  - Paul, Friedemann
A1  - Lynch, Sharon G.
A1  - Akinwuntan, Abiodun E.
A1  - Devos, Hannes
A1  - Hausdorff, Jeffrey M.
A1  - Sosnoff, Jacob J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: To explore the association between frailty and history of falls in people living with multiple sclerosis (MS). <br><br>DESIGN: Secondary analysis. SETTING: University research laboratories in the United States and Israel. PARTICIPANTS: 118 people with relapsing-remitting MS [age=48.9 years (SD=10.0); 74.6% female; expanded disability status scale (EDSS) range=1.0-6.0] were studied in this cross-sectional analysis. INTERVENTION: Not applicable. MAIN OUTCOMES: A frailty index was calculated from 40 health deficits by following standard validated procedures. The number of falls (12-month history) was recorded. <br><br>RESULTS: Overall, 33.9%, 29.7%, and 36.4% of participants were classified as non-frail, moderately frail, and severely frail, respectively. The frailty index was significantly correlated (ρ=0.37, p<0.001) with higher scores on the EDSS. In univariable negative binomial regression analysis, the frailty index was associated with a higher number of falls (IRR=3.33, 95%CI[1.85-5.99], p<0.001). After adjustment for age, gender and EDSS, frailty remained strongly associated with history of falls (IRR=2.78, 95%CI[1.51-5.10], p=0.001). <br><br>CONCLUSION: The current study identifies a significant relationship between frailty and history of falls in MS, independent of age, gender, and disease severity. These findings support the notion that frailty is a syndrome related to, but independent of, disability in MS.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-9993
UR  - http://dx.doi.org/10.1016/j.apmr.2021.10.025
ID  - ref1
ER  -