TY  - JOUR
PY  - 2021//
TI  - Postural sway characteristics are affected by Alzheimer's disease
JO  - Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
A1  - Ashiri, Mehrangiz
A1  - Francisco, Cristina
A1  - Winkler, Jeffrey
A1  - Lithgow, Brian
A1  - Moussavi, Zahra
SP  - 7219
EP  - 7222
VL  - 2021
IS  - 
N2  - The vestibular system, responsible for balance, is affected by Alzheimer's disease (AD). In this paper, linear and non-linear balance features were used to assess the postural stability of 13 AD individuals at mild stages in comparison with 16 healthy controls. Utilizing two accelerometers, the anterior-posterior (AP) and medial-lateral (ML) sways were recorded from the T2 vertebrae and lateral malleolus of participants standing on a solid and soft foam surface under both eyes-open and eyes-closed conditions. From the recorded signals, four features were extracted and used for statistical analysis: Number of Position Changes (NPC), Number of Non-Zero Accelerations (NNZA), Katz, and Higuchi fractal dimensions (KFD and HFD, respectively). The results show: 1) postural stability is significantly worse for the eyes-closed compared to eyes-open condition (P<0.05 for all features except HFD) as well as whilst standing on soft foam compared to the solid surface (P<0.05 for all features) in both groups; 2) balance perturbations were larger for AP sway than ML on both solid and foam surfaces in both groups (P<0.05 for NPC and NNZA); and 3) stationary balance is significantly poorer for AD individuals compared to controls (P<0.05 for all features). These observations show that both linear and non-linear characteristics of postural stability data have the potentials to be used as objective diagnostic aids for the detection of AD.<p />  <p>Language: en</p>
LA  - en
SN  - 2375-7477
UR  - http://dx.doi.org/10.1109/EMBC46164.2021.9630746
ID  - ref1
ER  -