TY  - JOUR
PY  - 2021//
TI  - The role of oxidative stress in suicidal behaviour among bipolar patients: a cross-sectional study in a Malaysian sample
JO  - Frontiers in psychiatry
A1  - Loo, Jiann Lin
A1  - Mohamad Kamal, Nurul Ain
A1  - Goon, Jo Aan
A1  - Ahmad Damanhuri, Hanafi
A1  - Tan, Jaclyn Ai Chin
A1  - Abdul Murad, Nor Azian
A1  - Shah, Shamsul Azhar
A1  - Sulaiman, Siti Aishah
A1  - Fazry, Shazrul
A1  - Sharip, Shalisah
A1  - Mohamed Saini, Suriati
A1  - Gunasekaran, Geetha
A1  - Maniam, Thambu
A1  - Jamal, A. Rahman A.
A1  - Wan Ngah, Wan Zurinah
A1  - Mohd Badli Shah, Fatimatul Syahirah
A1  - Chan, Lai Fong
SP  - e698911
EP  - e698911
VL  - 12
IS  - 
N2  - BACKGROUND: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to investigate the association between DNA damage and suicidal behaviour, i.e., suicidal ideation and suicide attempt, among suicidal ideators in BD patients while accounting for clinical and psychosocial risk factors. <br><br>METHODS: A cross-sectional study was conducted in the Universiti Kebangsaan Malaysia Medical Centre on 62 consecutive BD patients diagnosed using the M.I.N.I. Neuropsychiatric Interview and 26 healthy control participants. Socio-demographic and clinical assessments were performed using the Columbia Suicide Severity Rating Scale (C-SSRS) for lifetime suicidal ideation and attempt, Quick Inventory of Depressive Symptomatology (QIDS) for depression severity, Clinical Global Impression for Bipolar Disorder (CGI-BD) for illness severity [both mania (CGI-Mania) and major depressive episode (CGI-MDE)], Social Readjustment Rating Scale (SRRS) for change in life events, and Barratt Impulsiveness Scale (BIS) for behavioural impulsivity. The degree of DNA damage in peripheral blood samples was determined using a standard protocol of comet assay. <br><br>RESULTS: Multivariable logistic regression revealed higher scores of CGI-MDE as the sole significant factor for lifetime suicidal ideation (OR = 1.937, 95% CI = 1.799-2.076). Although initial bivariate analysis showed a significant association between DNA damage, malondialdehyde (MDA), catalase (CAT), and suicidal behaviour, the findings were not seen in multivariable logistic regression. Bivariate subgroup analysis showed that moderate and severe DNA damage (p = 0.032 and p = 0.047, respectively) was significantly associated with lifetime suicide attempts among lifetime suicidal ideators. The study is the first to look at the connexion between DNA damage and suicidal risk in bipolar patients. It is limited by the small sample size and lack of information on illicit substance use. <br><br>CONCLUSIONS: More severe DNA damage was significantly associated with lifetime suicide attempts among lifetime suicidal ideators in BD. However, the severity of depression was found to be independently associated with lifetime suicidal ideation per se rather than DNA damage in BD. Larger prospective studies are required to ascertain the potential of DNA damage as a biomarker for the transition from suicidal ideation to a suicide attempt.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-0640
UR  - http://dx.doi.org/10.3389/fpsyt.2021.698911
ID  - ref1
ER  -