TY  - JOUR
PY  - 2021//
TI  - A successful experience using labetalol and hemodialysis to treat near-fatal caffeine poisoning: a case report with toxicodynamics
JO  - American journal of emergency medicine
A1  - Ou, Hao-Cho
A1  - Deng, Jou-Fang
A1  - Yang, Chen-Chang
A1  - Lin, Chin-Sheng
A1  - Mao, Yan-Chiao
A1  - Tsai, Shih-Hung
A1  - Ho, Cheng-Hsuan
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Caffeine poisoning is relatively rare, and a near-fatal caffeine overdose is highly uncommon. We present an 18-year-old male who attempted suicide with 295 mg/kg pure caffeine powder (lethal oral dose: 150-200 mg/kg) and was successfully rescued. He presented with seizures, refractory supraventricular tachycardia and hypertension for 6 h with no response to medications and cardioversion. Even with the high level of caffeine, labetalol, which is seldom administered as a treatment for caffeine poisoning-induced tachycardia, successfully relieved refractory tachycardia. Then, hemodialysis ultimately eliminated serum caffeine and completely alleviated caffeine-related central nervous system toxicity. We discuss the clinical symptoms, management and toxicodynamics based on the concentration of caffeine and its metabolites in serum and urine.<p />  <p>Language: en</p>
LA  - en
SN  - 0735-6757
UR  - http://dx.doi.org/10.1016/j.ajem.2021.11.049
ID  - ref1
ER  -