TY  - JOUR
PY  - 2021//
TI  - Early pupillometry assessment in traumatic brain injury patients: a retrospective study
JO  - Brain sciences
A1  - Luz Teixeira, Thomas
A1  - Peluso, Lorenzo
A1  - Banco, Pierluigi
A1  - Njimi, Hassane
A1  - Abi-Khalil, Layal
A1  - Chanchay Pillajo, Mélanie
A1  - Schuind, Sophie
A1  - Creteur, Jacques
A1  - Bouzat, Pierre
A1  - Taccone, Fabio Silvio
SP  - e1657
EP  - e1657
VL  - 11
IS  - 12
N2  - BACKGROUND: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI). <br><br>METHODS: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Abnormal NPi was considered if <3. Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1-3. <br><br>RESULTS: 100 patients were included over the study period (median age 48 (34-69) years and median GCS on admission 11 (6-15)); 49 (49%) patients had UO. On admission, 20 (20%) patients had an abnormal NPi (NPi < 3); median worst (i.e., from both eyes) NPi was 4.2 (3.2-4.5). Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7-4.4) vs. 4.4 (3.7-4.6); p = 0.005-4.0 (2.6-4.5) vs. 4.5 (3.9-4.7); p = 0.002, respectively). The ROC curve for the worst and mean NPi showed a moderate accuracy to predict UO (AUC 0.66 (0.56-0.77); p = 0.005 and 0.68 (0.57-0.78); p = 0.002). However, in a generalized linear model, the prognostic role of NPi on admission was limited. <br><br>CONCLUSIONS: Low NPi on admission has limited prognostic value in TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 2076-3425
UR  - http://dx.doi.org/10.3390/brainsci11121657
ID  - ref1
ER  -