TY  - JOUR
PY  - 2022//
TI  - Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis
JO  - Epigenomics
A1  - Musanabaganwa, Clarisse
A1  - Wani, Agaz H.
A1  - Donglasan, Janelle
A1  - Fatumo, Segun
A1  - Jansen, Stefan
A1  - Mutabaruka, Jean
A1  - Rutembesa, Eugène
A1  - Uwineza, Annette
A1  - Hermans, Erno J.
A1  - Roozendaal, Benno
A1  - Wildman, Derek E.
A1  - Mutesa, Leon
A1  - Uddin, Monica
SP  - 11
EP  - 25
VL  - 14
IS  - 1
N2  - Aim & methods: We conducted a pilot epigenome-wide association study of women from Tutsi ethnicity exposed to the genocide while pregnant and their resulting offspring, and a comparison group of women who were pregnant at the time of the genocide but living outside of Rwanda.<br><br>RESULTS: Fifty-nine leukocyte-derived DNA samples survived quality control: 33 mothers (20 exposed, 13 unexposed) and 26 offspring (16 exposed, 10 unexposed). Twenty-four significant differentially methylated regions (DMRs) were identified in mothers and 16 in children. <br><br>CONCLUSIONS:In utero genocide exposure was associated with CpGs in three of the 24 DMRs: BCOR, PRDM8 and VWDE, with higher DNA methylation in exposed versus unexposed offspring. Of note, BCOR and VWDE show significant correlation between brain and blood DNA methylation within individuals, suggesting these peripherally derived signals of genocide exposure may have relevance to the brain.<p />
LA  - en
SN  - 1750-1911
UR  - http://dx.doi.org/10.2217/epi-2021-0310
ID  - ref1
ER  -