TY  - JOUR
PY  - 2022//
TI  - Neural processing dysfunctions during fear learning but not reward-related processing characterize depressed individuals with high levels of repetitive negative thinking
JO  - Biological psychiatry: cognitive neuroscience and neuroimaging
A1  - Park, Heekyeong
A1  - Kirlic, Namik
A1  - Kuplicki, Rayus
A1  - Paulus, Martin
A1  - Guinjoan, Salvador
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Repetitive Negative Thinking (RNT) is a symptom dimension of depression that is associated with a poorer prognosis in terms of higher recurrence, treatment resistance, residual symptoms, and disability. This investigation examined whether RNT is associated with aberrant reward processing and fear learning. <br><br>METHODS: Very High RNT [n=60] and High RNT [n=60] propensity-matched individuals with depression (age, sex, race/ethnicity, income/employment, body mass index, depressive and anxiety symptom severity) participated in the present study along with matched healthy comparison (HC) volunteers [n=30]. This propensity-matched sample was selected from the larger Tulsa-1000 study. Participants performed two functional magnetic resonance imaging tasks: the Monetary Incentive Delay task (MID) probing reward processing and the Fear Conditioning task probing aversive learning and extinction. <br><br>RESULTS: Both very high and high RNT groups (VH-RNT, H-RNT) showed lower neural activity than HC in reward circuitry including inferior frontal gyrus (VH-RNT: β = -1.24, H-RNT: β = -1.28) as well as the cerebellum (VH-RNT: β = -0.93, H-RNT: β = -1.14). However, individuals with VH-RNT exhibited lower activation than H-RNT in central autonomic network components during fear conditioning (β: -0.84) as well as continued conditioned responses during early extinction in the postcentral cortex (β: 0.71). <br><br>CONCLUSION: VH-RNT showed aberrant processing in fear conditioning during both learning and extinction phases, compared to H-RNT. These findings demonstrate that dysfunctions of negative valence associated with RNT may be domain-specific, which should be taken into account for identifying potential specific targets of intervention.<p />  <p>Language: en</p>
LA  - en
SN  - 2451-9030
UR  - http://dx.doi.org/10.1016/j.bpsc.2022.01.002
ID  - ref1
ER  -