TY  - JOUR
PY  - 2021//
TI  - A naturalistic, European multi-center clinical study of electrodermal reactivity and suicide risk among patients with depression
JO  - Frontiers in psychiatry
A1  - Carli, Vladimir
A1  - Hadlaczky, Gergo
A1  - Petros, Nuhamin Gebrewold
A1  - Iosue, Miriam
A1  - Zeppegno, Patrizia
A1  - Gramaglia, Carla
A1  - Amore, Mario
A1  - Baca-Garcia, Enrique
A1  - Batra, Anil
A1  - Cosman, Doina
A1  - Courtet, Philippe
A1  - Di Sciascio, Guido
A1  - Ekstrand, Joakim
A1  - Galfalvy, Hanga
A1  - Gusmäo, Ricardo
A1  - Jesus, Catarina
A1  - Heitor, Maria João
A1  - Constante, Miguel
A1  - Rad, Pouya Movahed
A1  - Saiz, Pilar A.
A1  - Wojnar, Marcin
A1  - Sarchiapone, Marco
SP  - e765128
EP  - e765128
VL  - 12
IS  - 
N2  - BACKGROUND: Electrodermal hyporeactivity has been proposed as a marker of suicidal risk. The EUDOR-A study investigated the prevalence of electrodermal hyporeactivity among patients with depression and its association with attempted and completed suicide. <br><br>METHODS: Between August 2014 and March 2016, 1,573 in- and outpatients with a primary diagnosis of depression (active or remission phase) were recruited at 15 European psychiatric centers. Each patient was followed-up for 1 year. Electrodermal activity was assessed at baseline with the ElectroDermal Orienting Reactivity Test. Data on the sociodemographic characteristics, clinical diagnoses, and treatment of the subjects were also collected. The severity of the depressive symptoms was assessed through the Montgomery-Asberg Depression Rating Scale. Information regarding number, time, and method of suicide attempts was gathered at baseline and at the end of the 1-year follow-up. The same data were collected in case of completed suicide. <br><br>RESULTS: Hyporeactive patients were shown to be significantly more at risk of suicide attempt compared to reactive patients, both at baseline and follow-up. A sensitivity of 29.86% and a positive predictive value (PPV) of 46.77% were found for attempted suicide at baseline, while a sensitivity of 35.36% and a PPV of 8.92% were found for attempted suicide at follow-up. The sensitivity and PPV for completed suicide were 25.00 and 0.61%, respectively. However, when controlled for suicide attempt at baseline, the association between hyporeactivity and follow-up suicide attempt was no longer significant. The low number of completed suicides did not allow any analysis.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-0640
UR  - http://dx.doi.org/10.3389/fpsyt.2021.765128
ID  - ref1
ER  -