TY  - JOUR
PY  - 2022//
TI  - Effects of multivitamin, mineral and n-3 polyunsaturated fatty acid supplementation on aggression among long-stay psychiatric in-patients: randomised clinical trial
JO  - BJPsych open
A1  - de Bles, Nienke J.
A1  - Rius-Ottenheim, Nathaly
A1  - Geleijnse, Johanna M.
A1  - van de Rest, Ondine
A1  - Bogers, Jan P. A. M.
A1  - Schat, Anke
A1  - Nijman, Henk L. I.
A1  - van den Berg, David
A1  - Joos, Lucas
A1  - van Strater, Annelies
A1  - de Ridder, Tine
A1  - Stolker, Joost J.
A1  - van den Hout, Wilbert B.
A1  - van Hemert, Albert M.
A1  - Giltay, Erik J.
SP  - e42
EP  - e42
VL  - 8
IS  - 2
N2  - BACKGROUND: Aggression and violent incidents are a major concern in psychiatric in-patient care. Nutritional supplementation has been found to reduce aggressive incidents and rule violations in forensic populations and children with behavioural problems. AIMS: To assess whether multivitamin, mineral and n-3 polyunsaturated fatty acid supplementation would reduce the number of aggressive incidents among long-stay psychiatric in-patients. <br><br>METHOD: The trial was a pragmatic, multicentre, randomised, double-blind placebo-controlled study. Data were collected from 25 July 2016 to 29 October 2019, at eight local sites for mental healthcare in The Netherlands and Belgium. Participants were randomised (1:1) to receive 6-month treatment with either three supplements containing multivitamins, minerals and n-3 polyunsaturated fatty acid, or placebo. The primary outcome was the number of aggressive incidents, determined by the Staff Observation Aggression Scale - Revised (SOAS-R). Secondary outcomes were patient quality of life, affective symptoms and adverse events. <br><br>RESULTS: In total, 176 participants were randomised (supplements, n = 87; placebo, n = 89). Participants were on average 49.3 years old (s.d. 14.5) and 64.2% were male. Most patients had a psychotic disorder (60.8%). The primary outcome of SOAS-R incidents was similar in supplement (1.03 incidents per month, 95% CI 0.74-1.37) and placebo groups (0.90 incidents per month, 95% CI 0.65-1.19), with a rate ratio of 1.08 (95% CI 0.67-1.74, P = 0.75). Differential effects were not found in sensitivity analyses on the SOAS-R or on secondary outcomes. <br><br>CONCLUSIONS: Six months of nutritional supplementation did not reduce aggressive incidents among long-stay psychiatric in-patients.<p />  <p>Language: en</p>
LA  - en
SN  - 2056-4724
UR  - http://dx.doi.org/10.1192/bjo.2022.8
ID  - ref1
ER  -