TY - JOUR
PY - 2022//
TI - Mortality and causes of death among people with convulsive epilepsy in northwestern China
JO - Epilepsy and behavior
A1 - Jin, Yanzi
A1 - Liu, Yujiao
A1 - Xu, Xianrui
A1 - Wang, Xu
A1 - Zhang, Qing
SP - e108492
EP - e108492
VL - 127
IS -
N2 - OBJECTIVE We analyzed mortality and causes of death among people with convulsive epilepsy in rural areas of northwestern China. Methods We established a population-based prospective cohort of people with convulsive epilepsy in an epilepsy prevention and management program in rural northwestern China from January 2012 to December 2013. A uniform cause of death questionnaire was used to obtain detailed information on participants who died during the follow-up until December 2016. We calculated the standardized mortality ratios (SMRs) and proportional mortality rate for major causes of death. Cox proportional hazards regression analysis was used to investigate the risk factors associated with mortality. Results Among 4296 people with convulsive epilepsy, 216 died during a median follow-up of 59 months. The overall mortality rate was 10.9 per 1000 person-years, and the overall SMR was 2.0. Accidents (25.5%) ranked first in the cause of death, followed by status epilepticus (SE) (22.9%), probable sudden unexpected death in epilepsy (SUDEP) (22.7%), cerebrovascular disease (13.0%), and cardiovascular disease (6.5%). Drowning (10.6%), motor vehicle accidents (13.6%), and falls (4.6%) were the major causes of death by accidents. Female participants had a reduced risk of death from accidents with the hazard ratio (HR) of 0.3 (95% confidence interval (CI): 0.1-0.6). A high risk of death from cerebrovascular disease (HR: 7.2; 95% CI: 2.1-23.6) was found in participants with an onset age of epilepsy older than 16 years. Significance The risk of death from convulsive epilepsy in rural northwestern China is twice that of the general population. Accidents, SE, and SUDEP are the leading putative causes of death. Educating people with epilepsy in different regions may help reduce death-related events. Language: en
LA - en
SN - 1525-5050
UR - http://dx.doi.org/10.1016/j.yebeh.2021.108492
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