TY  - JOUR
PY  - 2022//
TI  - Cerebellum anatomy predicts individual risk-taking behavior and risk tolerance
JO  - NeuroImage
A1  - Quan, Peng
A1  - He, Lisheng
A1  - Mao, Tianxin
A1  - Fang, Zhuo
A1  - Deng, Yao
A1  - Pan, Yu
A1  - Zhang, Xiaocui
A1  - Zhao, Ke
A1  - Lei, Hui
A1  - Detre, John A.
A1  - Kable, Joseph W.
A1  - Rao, Hengyi
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Human risk tolerance is highly idiosyncratic and individuals often show distinctive preferences when faced with similar risky situations. However, the neural underpinnings of individual differences in risk-taking remain unclear. Here we combined structural and perfusion MRI and examined the associations between brain anatomy and individual risk-taking behavior/risk tolerance in a sample of 115 healthy participants during the Balloon Analogue Risk Task, a well-established sequential risky decision paradigm. Both whole brain and region-of-interest analyses showed that the left cerebellum gray matter volume (GMV) has a strong association with individual risk-taking behavior and risk tolerance, outperforming the previously reported associations with the amygdala and right posterior parietal cortex (PPC) GMV. Left cerebellum GMV also accounted for risk tolerance and risk-taking behavior changes with aging. However, regional cerebral blood flow (CBF) provided no additional predictive power. These findings suggest a novel cerebellar anatomical contribution to individual differences in risk tolerance. Further studies are necessary to elucidate the underestimated important role of cerebellum in risk-taking.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8119
UR  - http://dx.doi.org/10.1016/j.neuroimage.2022.119148
ID  - ref1
ER  -