TY  - JOUR
PY  - 2022//
TI  - Assessment of hospitalizations of patients after intoxication with organophosphates used in agriculture
JO  - Annals of agricultural and environmental medicine
A1  - Orzeł, Anna Katarzyna
A1  - Flieger, Wojciech
A1  - Szlichta, Dominika
A1  - Terpiłowska, Barbara
A1  - Terpiłowski, Michał
A1  - Orzeł, Zbigniew
A1  - Tchórz, Michał
A1  - Szponar, Jarosław
SP  - 143
EP  - 148
VL  - 29
IS  - 1
N2  - INTRODUCTION: Clinical manifestation of organophosphates toxicity may be differentiate and include cholinergic toxidrome, intermediate syndrome, OP-induced delayed polyneuropathy to chronic OP-induced neuropsychiatric disorder (OPIDN). Patients symptoms, along with decrease in cholinesterase serum level, determines the possible diagnosis of organophosphate poisoning. <br><br>OBJECTIVE: The aim of the study was to present the clinical manifestation and cholinesterase level changes in intoxication with organophosphorus compounds in patients. MATERIAL AND METHODS: A data base was created by analysis of the hospital documents of 34 patients hospitalized due to organophosphate intoxication. Statistical analysis involved frequency tables with percentage values, the application of non-parametric Chi-square test and parametric t-Student test (with homogeneity of variance Levine test). The level of static significance was set to p=0.05. <br><br>RESULTS: In fatal hospitalizations (20.6%), cholinesterase level was significantly lower (265.87 U/l) than in other patients (4254.78 U/l; p<0.05). Similarly, levels of cholinesterase were decreased in group of patients with acute respiratory failure (999.79 U/l vs 4943.86 U/l in other patients; p<0.05), patients with multi-organ dysfunction syndrome (244.13 U/l vs 4914.89 U/l in other patients; p<0.05) and those with cardiac arrest (547 U/l vs 4636.25 U/l in other patients). A statistically significant difference was also observed in cholinesterase level of patients who required mechanical ventilation (548.17 U/l vs 5219.71 U/l in other group). The study revealed that 29.4% of poisonings were suicidal. <br><br>CONCLUSIONS: The management of a patient with organophosphate poisoning remains challenging and requires continuous control. A significant step in the diagnostic process is the assessment changes in both the clinical picture and cholinesterase level.<p />  <p>Language: en</p>
LA  - en
SN  - 1232-1966
UR  - http://dx.doi.org/10.26444/aaem/145769
ID  - ref1
ER  -