TY  - JOUR
PY  - 2022//
TI  - Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: a genomic structural equation modelling approach
JO  - Drug and alcohol dependence
A1  - Bountress, Kaitlin E.
A1  - Brick, Leslie A.
A1  - Sheerin, Christina
A1  - Grotzinger, Andrew
A1  - Bustamante, Daniel
A1  - Hawn, Sage E.
A1  - Gillespie, Nathan
A1  - Kirkpatrick, Robert M.
A1  - Kranzler, Henry
A1  - Morey, Rajendra
A1  - Edenberg, Howard J.
A1  - Maihofer, Adam X.
A1  - Disner, Seth
A1  - Ashley-Koch, Allison
A1  - Peterson, Roseann
A1  - Lori, Adriana
A1  - Stein, Dan J.
A1  - Kimbrel, Nathan
A1  - Nievergelt, Caroline
A1  - Andreassen, Ole A.
A1  - Luykx, Jurjen
A1  - Javanbakht, Arash
A1  - Youssef, Nagy A.
A1  - Amstadter, Ananda B.
SP  - e109430
EP  - e109430
VL  - 234
IS  - 
N2  - PURPOSE: Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the genetic association between PTSD and alcohol use differs from that of PTSD and AUD, but further analysis is needed. BASIC PROCEDURES: We used genomic Structural Equation Modeling (genomicSEM) to analyze summary statistics from large-scale genome-wide association studies (GWAS) of European Ancestry participants to investigate the genetic relationships between PTSD (both diagnosis and re-experiencing symptom severity) and a range of alcohol use and AUD phenotypes. MAIN FINDINGS: When we differentiated genetic factors for alcohol use and AUD we observed improved model fit relative to models with all alcohol-related indicators loading onto a single factor. The genetic correlations (rG) of PTSD were quite discrepant for the alcohol use and AUD factors. This was true when modeled as a three-correlated-factor model (PTSD-AUD rG:.36, p < .001; PTSD-alcohol use rG: -0.17, p < .001) and as a Bifactor model, in which the common and unique portions of alcohol phenotypes were pulled out into an AUD-specific factor (rG with PTSD:.40, p < .001), AU-specific factor (rG with PTSD: -0.57, p < .001), and a common alcohol factor (rG with PTSD:.16, NS). PRINCIPAL CONCLUSIONS: These results indicate the genetic architecture of alcohol use and AUD are differentially associated with PTSD. When the portions of variance unique to alcohol use and AUD are extracted, their genetic associations with PTSD vary substantially, suggesting different genetic architectures of alcohol phenotypes in people with PTSD.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2022.109430
ID  - ref1
ER  -