TY  - JOUR
PY  - 2022//
TI  - Preliminary evidence that the short allele of 5-HTTLPR moderates the association of psychiatric symptom severity on suicide attempt: the example in obsessive-compulsive disorder
JO  - Frontiers in psychiatry
A1  - Harika-Germaneau, Ghina
A1  - Lafay-Chebassier, Claire
A1  - Langbour, Nicolas
A1  - Thirioux, Bérangère
A1  - Wassouf, Issa
A1  - Noel, Xavier
A1  - Jaafari, Nemat
A1  - Chatard, Armand
SP  - e770414
EP  - e770414
VL  - 13
IS  - 
N2  - BACKGROUND: The severity of symptoms represents an important source of distress in patients with a psychiatric disease. However, the extent to which this endogenous stress factor interacts with genetic vulnerability factors for predicting suicide risks remains unclear. <br><br>METHODS: We evaluated whether the severity of symptoms interacts with a genetic vulnerability factor (the serotonin transporter gene-linked promoter region variation) in predicting the frequency of lifetime suicide attempts in patients with a psychiatric disease. Symptom severity and 5-HTTLPR polymorphism were collected from a sample of 95 patients with obsessive-compulsive disorder (OCD). Lifetime suicide attempt was the primary outcome, and antecedent of multiple suicide attempts was the secondary outcome. <br><br>RESULTS: The gene-by-symptoms interaction was associated with an excess risk of suicide attempts (OR = 4.39, 95CI[1.44, 13.38], p < 0.009) and of multiple suicide attempts (OR = 4.18, 95CI[1.04, 16.77], p = 0.043). Symptom severity (moderate, severe, or extreme) was associated with an approximately five-fold increase in the odds of a lifetime suicide attempt in patients carrying one or two copies of the short allele of 5-HTTLPR. No such relationship was found for patients carrying the long allele. <br><br>CONCLUSION: This study provides preliminary evidence for the gene-by-stress interaction on suicide attempt when stress is operationalized as symptom severity. Progress in suicide research may come from efforts to investigate the gene-by-symptoms interaction hypothesis in a variety of diseases.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-0640
UR  - http://dx.doi.org/10.3389/fpsyt.2022.770414
ID  - ref1
ER  -