TY  - JOUR
PY  - 2022//
TI  - Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning
JO  - Translational psychiatry
A1  - Owens, Max M.
A1  - Albaugh, Matthew D.
A1  - Allgaier, Nicholas
A1  - Yuan, Dekang
A1  - Robert, Gabriel
A1  - Cupertino, Renata B.
A1  - Spechler, Philip A.
A1  - Juliano, Anthony
A1  - Hahn, Sage
A1  - Banaschewski, Tobias
A1  - Bokde, Arun L. W.
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Grigis, Antoine
A1  - Gowland, Penny
A1  - Heinz, Andreas
A1  - Brühl, Rüdiger
A1  - Martinot, Jean-Luc
A1  - Martinot, Marie-Laure Paillère
A1  - Artiges, Eric
A1  - Nees, Frauke
A1  - Orfanos, Dimitri Papadopoulos
A1  - Lemaitre, Herve
A1  - Paus, Tomas
A1  - Poustka, Luise
A1  - Millenet, Sabina
A1  - Fröhner, Juliane H.
A1  - Smolka, Michael N.
A1  - Walter, Henrik
A1  - Whelan, Robert
A1  - Mackey, Scott
A1  - Schumann, Gunter
A1  - Garavan, Hugh
SP  - e188
EP  - e188
VL  - 12
IS  - 1
N2  - While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationships in correlational data using conditional probabilities to estimate directional associations between a set of interrelated variables. In this study, we employed BCN modeling in 637 adolescents from the IMAGEN study who were cannabis naïve at age 14 to provide evidence that the accelerated prefrontal cortical thinning found previously in adolescent cannabis users by Albaugh et al. [1] is a result of cannabis use causally affecting neurodevelopment. BCNs incorporated data on cannabis use, prefrontal cortical thickness, and other factors related to both brain development and cannabis use, including demographics, psychopathology, childhood adversity, and other substance use. All BCN algorithms strongly suggested a directional relationship from adolescent cannabis use to accelerated cortical thinning. While BCN modeling alone does not prove a causal relationship, these results are consistent with a body of animal and human research suggesting that adolescent cannabis use adversely affects brain development.<p />  <p>Language: en</p>
LA  - en
SN  - 2158-3188
UR  - http://dx.doi.org/10.1038/s41398-022-01956-4
ID  - ref1
ER  -