TY  - JOUR
PY  - 2022//
TI  - Association of lifetime major depressive disorder with enhanced attentional sensitivity measured with P3 response in young adult twins
JO  - Biological psychology
A1  - Koskinen, Sini M.
A1  - Ahveninen, Jyrki
A1  - Kujala, Teija
A1  - Kaprio, Jaakko
A1  - O'Donnell, Brian F.
A1  - Osipova, Daria
A1  - Viken, Richard J.
A1  - Näätänen, Risto
A1  - Rose, Richard J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Major depression is associated with alterations in the auditory P3 event-related potential (ERP). However, the persistence of these abnormalities after recovery from depressive episodes, especially in young adults, is not well known. Furthermore, the potential influence of substance use on this association is poorly understood. Young adult twin pairs (N=177) from the longitudinal FinnTwin16 study were studied with a psychiatric interview, and P3a and P3b ERPs elicited by task-irrelevant novel sounds and targets, respectively. Dyadic linear mixed-effect models were used to distinguish the effects of lifetime major depressive disorder from familial factors and effects of alcohol problem drinking and tobacco smoking. P3a amplitude was significantly increased and P3b latency decreased, in individuals with a history of lifetime major depression, when controlling the fixed effects of alcohol abuse, tobacco, gender, twins' birth order, and zygosity. These results suggest that past lifetime major depressive disorder may be associated with enhanced attentional sensitivity.<p />  <p>Language: en</p>
LA  - en
SN  - 0301-0511
UR  - http://dx.doi.org/10.1016/j.biopsycho.2022.108345
ID  - ref1
ER  -