TY  - JOUR
PY  - 2022//
TI  - What role for cognitive remediation in the treatment of depressive symptoms? A superiority and noninferiority meta-analysis for clinicians
JO  - Depression and anxiety
A1  - Sociali, Antonella
A1  - Borgi, Marta
A1  - Pettorruso, Mauro
A1  - Di Carlo, Francesco
A1  - Di Natale, Chiara
A1  - Tambelli, Antonio
A1  - Alessi, Maria C.
A1  - Ciavoni, Laura
A1  - Mosca, Alessio
A1  - Miuli, Andrea
A1  - Sensi, Stefano L.
A1  - Martinotti, Giovanni
A1  - Zoratto, Francesca
A1  - di Giannantonio, Massimo
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Cognitive remediation (CR) is a promising technique in the treatment of the cognitive dimension of depression. The present study evaluated the potential of CR in treating depressive symptoms and provides practical information about its usefulness in clinical settings. <br><br>METHODS: We performed two meta-analyses of published randomized (and nonrandomized) clinical trials, comparing CR to control conditions in subjects with current depressive symptomatology. The superiority meta-analysis aimed to determine the superiority of CR when compared with placebo/waiting list interventions and its efficacy when used as an augmentation therapy. The noninferiority meta-analysis determined whether CR had noninferior efficacy compared with standard antidepressant interventions. <br><br>RESULTS: CR was found to significantly improve depressive symptomatology in the superiority meta-analysis (CR: n = 466, control n = 478). Moreover, CR seemed to be noninferior to standard antidepressant interventions (CR: n = 230, control n = 235). CR was more effective when addressing hot (vs. cold) cognition, when involving younger patients (i.e., <30 years), and in the case of mild-moderate (vs. severe) depression. <br><br>CONCLUSIONS: CR should be considered an augmentation treatment to improve treatment outcomes in depressed subjects, especially among young individuals. Interventions addressing hot cognition seem to be the most promising.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.23263
ID  - ref1
ER  -