TY  - JOUR
PY  - 2022//
TI  - Short-term mortality following tramadol poisonings in Denmark
JO  - Basic and Clinical Pharmacology and Toxicology
A1  - Sørensen, Anne Mette Skov
A1  - Petersen, Janne
A1  - Christensen, Mikkel Bring
A1  - Schelde, Astrid Blicher
A1  - Andersen, Jon Traerup
A1  - Jimenez Solem, Espen
A1  - Petersen, Tonny Studsgaard
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Tramadol is a commonly used opioid with a potential of addiction and abuse. Using Danish nationwide registers, we aimed to 1) characterise opioid poisonings, 2) assess the 30-day mortality following morphine, oxycodone, and mixed poisonings compared to tramadol poisonings, and 3) assess the development in tramadol poisonings during a 12-year period. Poisonings were identified from 2006 to 2017. A Cox proportional hazards regression model was used to estimate adjusted hazard ratios (aHRs) along with 95% confidence intervals (CIs) for 30-day mortality following morphine, oxycodone, or mixed poisonings compared to tramadol poisonings. We identified 7,718 opioid poisonings among 6,365 patients. Patients with a tramadol poisoning were younger and had less comorbidities than patients with a morphine, oxycodone, or mixed poisoning. Within 30 days, a total of 205 patients died. The 30-day mortality risk was higher following morphine (aHR 3.2, 95% CI 2.0-5.1), oxycodone (aHR 2.1, 95% CI 1.2-3.6), and mixed poisonings (aHR 1.6, 95% CI 1.0-2.7) compared to tramadol poisonings. The annual number of tramadol poisonings increased from 233 in 2006 to 501 in 2013 and declined to 348 in 2017. In conclusion, despite a lower mortality risk compared to other opioid poisonings, physicians should consider the poisoning and abuse risks when prescribing tramadol.<p />  <p>Language: en</p>
LA  - en
SN  - 1742-7835
UR  - http://dx.doi.org/10.1111/bcpt.13741
ID  - ref1
ER  -