TY  - JOUR
PY  - 2022//
TI  - History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia
JO  - Brain imaging and behavior
A1  - Yin, Yi
A1  - Tong, Jinghui
A1  - Huang, Junchao
A1  - Tian, Baopeng
A1  - Chen, Song
A1  - Tan, Shuping
A1  - Wang, Zhiren
A1  - Yang, Fude
A1  - Tong, Yongsheng
A1  - Fan, Fengmei
A1  - Kochunov, Peter
A1  - Jahanshad, Neda
A1  - Li, Chiang-Shan R.
A1  - Hong, L. Elliot
A1  - Tan, Yunlong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Individuals with schizophrenia have higher rates of suicide attempts than the general population. Specific cortical abnormalities (e.g., the cortical surface area and thickness) may be associated with a history of suicide attempts. We recruited 74 individuals with schizophrenia (37 suicide attempters were individually matched with 37 non-attempters on age, sex, phase of illness, and study center) and 37 healthy volunteers. The cortical surface area and thickness data were extracted from structural MRI and compared between the groups. Suicide attempters showed significantly smaller surface areas in the whole brain (p = .028, Cohen's d = -0.54) than non-attempters. No association was found between the cortical surface area of individual brain regions and a history of suicide attempts. The mean cortical thickness did not differ significantly between the groups; however, suicide attempters demonstrated a thinner cortex in the right superior temporal gyrus (p < .001, q = 0.037, Cohen's d = -0.88). These findings indicate that a history of suicide attempts among individuals with schizophrenia is associated with a reduction in the global cortical surface area and specific cortical thinning of the right superior temporal gyrus. The morphometric alteration of the right superior temporal gyrus may represent a biomarker of suicidal behavior in individuals with schizophrenia.<p />  <p>Language: en</p>
LA  - en
SN  - 1931-7557
UR  - http://dx.doi.org/10.1007/s11682-021-00624-3
ID  - ref1
ER  -