TY  - JOUR
PY  - 2022//
TI  - Elevated axonal protein markers following repetitive blast exposure in military personnel
JO  - Frontiers in neuroscience
A1  - Vorn, Rany
A1  - Naunheim, Rosanne
A1  - Lai, Chen
A1  - Wagner, Chelsea
A1  - Gill, Jessica M.
SP  - e853616
EP  - e853616
VL  - 16
IS  - 
N2  - Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposure to blast-related training. Thirty-four military personnel who participated in the training program were included in this study. Blood samples were collected before and after repetitive blast-related training on days 2 (n = 19) and days 7 (n = 15). Serum concentration (pg/mL) of tau, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) were measured using an ultrasensitive immunoassay platform. We observed that serum p-tau181 concentrations were elevated after exposed to repetitive blast on days 2 (z = -2.983, p = 0.003) and days 7 (z = -2.158, p = 0.031). Serum tau (z = -2.272, p = 0.023) and NfL (z = -2.158, p = 0.031) levels were significantly elevated after exposure to repetitive blasts on days 7. Our findings indicate that blast exposure affects serum biomarkers indicating axonal injury.<p />  <p>Language: en</p>
LA  - en
SN  - 1662-4548
UR  - http://dx.doi.org/10.3389/fnins.2022.853616
ID  - ref1
ER  -