TY  - JOUR
PY  - 2022//
TI  - Intimate partner violence and oral HIV pre-exposure prophylaxis adherence among young African women
JO  - AIDS
A1  - Delanymoretlwe, Sinead
A1  - Celum, Connie
A1  - Pence, Brian W.
A1  - Hightow-Weidman, Lisa
A1  - Powers, Kimberly A.
A1  - Pettifor, Audrey
A1  - Giovenco, Danielle
A1  - Hosek, Sybil
A1  - Donnell, Deborah
A1  - Anderson, Peter L.
A1  - Mgodi, Nyaradzo
A1  - Bekker, Linda-Gail
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: To estimate the effect of intimate partner violence (IPV) on oral PrEP adherence among adolescent girls and young women (AGYW). <br><br>DESIGN: We conducted a secondary analysis of data from HIV Prevention Trials Network 082 (HPTN 082), a multisite prospective study designed to assess oral PrEP adherence among AGYW in southern Africa. <br><br>METHODS: We estimated the relative prevalence of high PrEP adherence 3 and 6 months after initiation among AGYW 16-25 years who reported a history of any IPV in the past year at enrollment versus AGYW who did not, both overall and by age. High adherence was defined as an intracellular tenofovir-diphosphate concentration at least 700 fmol/punch in dried blood spots. <br><br>RESULTS: Among 409 PrEP-initiating AGYW, half (49%) reported experiencing any IPV by a current/recent partner in the year prior to enrollment. Overall, a similar proportion of AGYW who reported IPV had high PrEP adherence at months 3 and 6 as AGYW who did not report IPV. There was, however, evidence of effect modification by age at month 3: among AGYW less than 21 years, those who reported IPV were less than half as likely to have high adherence [adjusted PR (aPR) = 0.43, 95% confidence interval (CI) 0.22-0.86]; among AGYW aged 21 years, those who reported IPV were more than twice as likely to have high adherence (aPR = 2.21, 95% CI 1.34-3.66). At month 6, effect estimates within each age stratum were consistent in direction to those at month 3. <br><br>CONCLUSION: IPV events may either impede or motivate PrEP adherence among African AGYW, with age appearing to be an important consideration for IPV-related adherence interventions.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9370
UR  - http://dx.doi.org/10.1097/QAD.0000000000003216
ID  - ref1
ER  -