TY  - JOUR
PY  - 2022//
TI  - School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study
JO  - Nordic journal of psychiatry
A1  - Sørensen, Holger J.
A1  - Antonsen, Sussie
A1  - Benros, Michael E.
A1  - Erlangsen, Annette
A1  - Albiñana, Clara
A1  - Nordentoft, Merete
A1  - Børglum, Anders D.
A1  - Mors, Ole
A1  - Werge, Thomas
A1  - Mortensen, Preben B.
A1  - Hougaard, David
A1  - Webb, Roger T.
A1  - Agerbo, Esben
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRS(MDD)) and for educational attainment (PRS(EDU)). <br><br>METHOD: We conducted a follow-up study of individuals born 1987-98 and followed from age 18 until 2016. The total sample consisted of a case group (23,779 diagnosed with mental disorders; schizophrenia, bipolar disorder, depression, autism, and attention deficit hyperactivity disorder (ADHD) and a randomly sampled comparison group (n = 10,925). Genome-wide data were obtained from the Neonatal Screening Biobank and information on school performance, family psychiatric history, and socioeconomic status from national administrative registers. <br><br>RESULTS: Individuals in the top PRS(MDD) decile were at higher self-harm risk in the case group (IRR: 1.30; 95% CI 1.15-1.46), whereas individuals in the top PRS(EDU) decile were at lower self-harm risk (IRR: 0.63; 95% CI: 0.55-0.74). Poorer school performance was associated with higher self-harm risk in persons diagnosed with any mental disorder (IRR: 1.69; 95% CI: 1.44-1.99) and among the comparison group (IRR: 7.93; 95% CI: 4.47-15.18). Observed effects of PRS(MDD) and PRS(EDU) on self-harm risk were strongest for individuals with poor school performance. <br><br>CONCLUSION: Associations between PRS(MDD) and self-harm risk and between PRS(EDU) and self-harm risk were found. Nevertheless, these polygenic scores seem currently of limited clinical utility for identifying individuals at high self-harm risk.<p />  <p>Language: en</p>
LA  - en
SN  - 0803-9488
UR  - http://dx.doi.org/10.1080/08039488.2022.2078998
ID  - ref1
ER  -