TY  - JOUR
PY  - 2022//
TI  - Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers
JO  - Alzheimer's and dementia
A1  - Weiner, Michael W.
A1  - Harvey, Danielle
A1  - Landau, Susan M.
A1  - Veitch, Dallas P.
A1  - Neylan, Thomas C.
A1  - Grafman, Jordan H.
A1  - Aisen, Paul S.
A1  - Petersen, Ronald C.
A1  - Jack, Clifford R. Jr
A1  - Tosun, Duygu
A1  - Shaw, Leslie M.
A1  - Trojanowski, John Q.
A1  - Saykin, Andrew J.
A1  - Hayes, Jacqueline
A1  - De Carli, Charles
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: Epidemiological studies report an association between traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker-defined AD. <br><br>METHODS: We identified 289 non-demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aβ) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years. <br><br>RESULTS: Exposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P < .0001) and worse Mini-Mental State Examination scores (PTSD: P = .008; TBI & PTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aβ or tau accumulation, or in most longitudinal measures. <br><br>DISCUSSION: TBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.<p />  <p>Language: en</p>
LA  - en
SN  - 1552-5260
UR  - http://dx.doi.org/10.1002/alz.12712
ID  - ref1
ER  -