TY  - JOUR
PY  - 2022//
TI  - Effectiveness and cost-effectiveness of universal school-based mindfulness training compared with normal school provision in reducing risk of mental health problems and promoting well-being in adolescence: the MYRIAD cluster randomised controlled trial
JO  - Evidence-based mental health
A1  - Kuyken, Willem
A1  - Ball, Susan
A1  - Crane, Catherine
A1  - Ganguli, Poushali
A1  - Jones, Benjamin
A1  - Montero-Marín, Jesus
A1  - Nuthall, Elizabeth
A1  - Raja, Anam
A1  - Taylor, Laura
A1  - Tudor, Kate
A1  - Viner, Russell M.
A1  - Allwood, Matthew
A1  - Aukland, Louise
A1  - Dunning, Darren
A1  - Casey, Tríona
A1  - Dalrymple, Nicola
A1  - Wilde, Katherine De
A1  - Farley, Eleanor-Rose
A1  - Harper, Jennifer
A1  - Kappelmann, Nils
A1  - Kempnich, Maria
A1  - Lord, Liz
A1  - Medlicott, Emma
A1  - Palmer, Lucy
A1  - Petit, Ariane
A1  - Philips, Alice
A1  - Pryor-Nitsch, Isobel
A1  - Radley, Lucy
A1  - Sonley, Anna
A1  - Shackleford, Jem
A1  - Tickell, Alice
A1  - Blakemore, Sarah-Jayne
A1  - Team, The MYRIAD
A1  - Ukoumunne, Obioha C.
A1  - Greenberg, Mark T.
A1  - Ford, Tamsin
A1  - Dalgleish, Tim
A1  - Byford, Sarah
A1  - Williams, J. Mark G.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Background Systematic reviews suggest school-based mindfulness training (SBMT) shows promise in promoting student mental health.   Objective The My Resilience in Adolescence (MYRIAD) Trial evaluated the effectiveness and cost-effectiveness of SBMT compared with teaching-as-usual (TAU).   Methods MYRIAD was a parallel group, cluster-randomised controlled trial. Eighty-five eligible schools consented and were randomised 1:1 to TAU (43 schools, 4232 students) or SBMT (42 schools, 4144 students), stratified by school size, quality, type, deprivation and region. Schools and students (mean (SD); age range=12.2 (0.6); 11-14 years) were broadly UK population-representative. Forty-three schools (n=3678 pupils; 86.9%) delivering SBMT, and 41 schools (n=3572; 86.2%) delivering TAU, provided primary end-point data. SBMT comprised 10 lessons of psychoeducation and mindfulness practices. TAU comprised standard social-emotional teaching. Participant-level risk for depression, social-emotional-behavioural functioning and well-being at 1 year follow-up were the co-primary outcomes. Secondary and economic outcomes were included.   Findings Analysis of 84 schools (n=8376 participants) found no evidence that SBMT was superior to TAU at 1 year. Standardised mean differences (intervention minus control) were: 0.005 (95% CI −0.05 to 0.06) for risk for depression; 0.02 (−0.02 to 0.07) for social-emotional-behavioural functioning; and 0.02 (−0.03 to 0.07) for well-being. SBMT had a high probability of cost-effectiveness (83%) at a willingness-to-pay threshold of £20 000 per quality-adjusted life year. No intervention-related adverse events were observed.   Conclusions Findings do not support the superiority of SBMT over TAU in promoting mental health in adolescence.   Clinical implications There is need to ask what works, for whom and how, as well as considering key contextual and implementation factors.   Trial registration Current controlled trials ISRCTN86619085. This research was funded by the Wellcome Trust (WT104908/Z/14/Z and WT107496/Z/15/Z).<p />  <p>Language: en</p>
LA  - en
SN  - 1362-0347
UR  - http://dx.doi.org/10.1136/ebmental-2021-300396
ID  - ref1
ER  -