TY  - JOUR
PY  - 2022//
TI  - Binge alcohol drinking before pregnancy is closely associated with the development of macrosomia: Korean pregnancy registry cohort
JO  - PLoS one
A1  - Koo, Seul
A1  - Kim, Ji Yeon
A1  - Park, Ji Hye
A1  - Roh, Gu Seob
A1  - Lim, Nam Kyoo
A1  - Park, Hyun Young
A1  - Kim, Won-Ho
SP  - e0271291
EP  - e0271291
VL  - 17
IS  - 7
N2  - BACKGROUND: Alcohol drinking during pregnancy has been well-known to cause the detrimental effects on fetal development; however, the adverse effects of pre-pregnancy drinking are largely unknown. We investigate whether alcohol drinking status before pregnancy is associated with the risk for macrosomia, an offspring's adverse outcome, in a Korean pregnancy registry cohort (n = 4,542) enrolled between 2013 and 2017. <br><br>METHODS: Binge drinking was defined as consuming ≥5 drinks on one occasion and ≥2 times a week, and a total 2,886 pregnant, included in the final statistical analysis, were divided into 3 groups: never, non-binge, and binge drinking. <br><br>RESULTS: The prevalence of macrosomia was higher in binge drinking before pregnancy than those with never or non-binge drinking (7.5% vs. 3.2% or 2.9%, p = 0.002). Multivariable logistic regression analysis demonstrated an independent association between macrosomia and prepregnancy binge drinking after adjusting for other confounders (adjusted odds ratio = 2.29; 95% CI, 1.08-4.86; p = 0.031). The model added binge drinking before pregnancy led to improvement of 10.6% (95% CI, 2.03-19.07; p = 0.0006) in discrimination from traditional risk prediction models. <br><br>CONCLUSION: Together, binge drinking before pregnancy might be an independent risk factor for developing macrosomia. Intensified intervention for drinking alcohol in women who are planning a pregnancy is important and may help prevent macrosomia.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0271291
ID  - ref1
ER  -