TY  - JOUR
PY  - 2022//
TI  - Impact of the Lubrizol factory fire in Rouen on coronary events: a retrospective study from the France PCI registry
JO  - Archives of cardiovascular diseases
A1  - Levesque, Thomas
A1  - Koning, René
A1  - Gillibert, André
A1  - Hohweyer, Jeanne
A1  - Bonnet, Philippe
A1  - Lesault, Pierre-François
A1  - Motreff, Pascal
A1  - Eltchaninoff, Hélène
A1  - Rangé, Gregoire
A1  - Durand, Eric
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: On 26 September 2019, an industrial fire occurred in the Lubrizol factory in Rouen (France), exposing the population to the inhalation of many volatile toxic agents secondary to combustion. <br><br>AIM: To assess the impact of the Lubrizol factory fire on the incidence of coronary artery events. <br><br>METHODS: All coronary angiograms performed in Rouen (exposed) and Le Havre (unexposed) from May 2019 to December 2019 were extracted from the prospective France Percutaneous Coronary Intervention (France PCI) registry. To study the impact of the fire on coronary events, an interrupted time series analysis was performed in Rouen, with adjustment on Le Havre in an autoregressive moving average (ARMA)(1,1) model with the precision of 1 week. The primary outcome was the incidence of acute coronary syndrome, and the secondary outcome was the incidence of ST-segment elevation myocardial infarction. <br><br>RESULTS: The mean number of acute coronary syndromes per week in the exposed zone (Rouen) increased non-significantly from 37.5±9.4 before the fire to 43.2±6.2 after the fire, for an estimated effect of +5.5 (95% confidence interval -0.7 to 11.8; P=0.09) events per week. In municipalities exposed to the plume of smoke (subgroup of Rouen), the mean number of acute coronary syndromes increased non-significantly from 7.3±2.8 before the fire to 8.7±3.6 after the fire, for an estimated effect of +1.0 (95% confidence interval -2.0 to 4.0; P=0.51) events per week. The results were similar when taking into account only ST-segment elevation myocardial infarctions or all coronary events. <br><br>CONCLUSIONS: Our study did not find a significant effect of the Lubrizol factory fire on the incidence of acute coronary syndrome. Further studies are needed to investigate the impact of industrial accidents on air pollution and coronary events.<p />  <p>Language: en</p>
LA  - en
SN  - 1875-2136
UR  - http://dx.doi.org/10.1016/j.acvd.2022.05.003
ID  - ref1
ER  -