TY  - JOUR
PY  - 2022//
TI  - Association between serum uric acid levels and suicide attempts in adolescents and young adults with major depressive disorder: a retrospective study
JO  - Neuropsychiatric disease and treatment
A1  - Kong, Yiting
A1  - Liu, Chuan
A1  - Zhang, Chenyu
A1  - Wang, Wo
A1  - Li, Yalan
A1  - Qiu, Haitang
A1  - Wang, Gaomao
A1  - Li, Daqi
A1  - Chen, Xiaorong
A1  - Lv, Zhen
A1  - Zhou, Dongdong
A1  - Wan, Liyang
A1  - Ai, Ming
A1  - Chen, Jianmei
A1  - Ran, Liuyi
A1  - Kuang, Li
SP  - 1469
EP  - 1477
VL  - 18
IS  - 
N2  - PURPOSE: Uric acid (UA) is thought to exert neuroprotective roles. The purpose of this study was to examine the association of serum UA with suicide attempts (SA) in adolescents and young adults with major depressive disorder (MDD). <br><br>PATIENTS AND METHODS: We retrospectively recruited 533 participants with MDD aged 13 to 25 years, of which 168 had a history of SA in the past three months and 365 did not have a history of SA. Serum UA levels were measured using the uricase-peroxidase coupling method. In addition to overall serum UA level comparison in MDD individuals with and without SA, a stratified analysis by biological sex was carried out. <br><br>RESULTS: Compared to MDD individuals without a history of SA, serum UA levels were significantly lower in MDD individuals with SA (P < 0.001). Female MDD, but not male MDD individuals, with SA exhibited lower levels of UA than those without SA (P < 0.01). Importantly, serum UA remained significantly associated with SA in MDD individuals (OR = 0.996, 95% CI: 0.993~0.999, P < 0.01) when controlling for possible confounding variables. <br><br>CONCLUSION: This research identifies a relationship between serum UA levels and SA in adolescents and young adults with MDD. UA may represent a biological risk marker for SA, in particular for female MDD individuals.<p />  <p>Language: en</p>
LA  - en
SN  - 1176-6328
UR  - http://dx.doi.org/10.2147/NDT.S368471
ID  - ref1
ER  -