TY - JOUR PY - 2022// TI - Prevalence and associations of classic psychedelic-related seizures in a population-based sample JO - Drug and alcohol dependence A1 - Simonsson, Otto A1 - Goldberg, Simon B. A1 - Chambers, Richard A1 - Osika, Walter A1 - Long, Dustin M. A1 - Hendricks, Peter S. SP - e109586 EP - e109586 VL - 239 IS - N2 - OBJECTIVES: Previous studies have reported links between classic psychedelic use and seizures, but little remains known about prevalence and potential risk factors of classic psychedelic-related seizures.

METHODS: Using a sample representative of the US adult population with regard to sex, age, and ethnicity (N = 2822), this study examined the prevalence and potential risk factors of classic psychedelic-related seizures, in a subsample of respondents who reported lifetime classic psychedelic use (n = 613).

RESULTS: Among those who reported lifetime classic psychedelic use, 1.5 % reported classic psychedelic-related seizures, a statistic that comports with the prevalence of epilepsy in the US population. Among those who reported seizures while using a classic psychedelic, almost half reported co-use of antidepressants, mood stabilizers, or opioid replacement therapies at the time of the seizures. Notably, classic psychedelic-related seizures were more commonly reported in certain respondents, especially those with a personal or family history of epilepsy.

CONCLUSIONS: These results suggest that classic psychedelic use could increase the risk of seizures in certain populations, particularly those with a personal or family history of epilepsy.

Language: en

LA - en SN - 0376-8716 UR - http://dx.doi.org/10.1016/j.drugalcdep.2022.109586 ID - ref1 ER -