TY  - JOUR
PY  - 2022//
TI  - Neurocognition and its association with adverse childhood experiences and familial risk of mental illness
JO  - Progress in neuro-psychopharmacology and biological psychiatry
A1  - Lakkireddy, Sai Priya
A1  - Balachander, Srinivas
A1  - Dayalamurthy, Pavithra
A1  - Bhattacharya, Mahashweta
A1  - Joseph, Mino Susan
A1  - Kumar, Pramod
A1  - Kannampuzha, Anand Jose
A1  - Mallappagari, Sreenivasulu
A1  - Narayana, Shruthi
A1  - Alexander, Alen Chandy
A1  - Moorthy, Muthukumaran
A1  - Sheth, Sweta
A1  - Puzhakkal, Joan C.
A1  - Ramesh, Vinutha
A1  - Thatikonda, Navya Spurthi
A1  - Selvaraj, Sowmya
A1  - Ithal, Dhruva
A1  - Sreeraj, Vanteemar S.
A1  - Mahadevan, Jayant
A1  - Holla, Bharath
A1  - Venkatasubramanian, Ganesan
A1  - John, John P.
A1  - Murthy, Pratima
A1  - Benegal, Vivek
A1  - Reddy, Y. C. Janardhan
A1  - Jain, Sanjeev
A1  - Viswanath, Biju
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Environmental factors such as adverse childhood experiences (ACEs) may affect neurocognition, an endophenotype for several mental illnesses. This study examines the effect of ACEs on neurocognitive performance in first-degree relatives (FDRs) of patients with severe mental illness to determine whether familial risk has a moderating effect on the relationship between ACEs and neurocognition. Unaffected FDRs from multiplex families with severe mental illnesses (schizophrenia, bipolar disorder, obsessive-compulsive disorder, or alcohol use disorder) (n = 324) and healthy controls (with no familial risk) (n = 188) underwent neurocognitive tests for processing speed, new learning, working memory and Theory of Mind. ACEs were measured using the WHO ACE-International Questionnaire (ACE-IQ). Regression models were done to predict each neurocognitive domain by the effect of familial risk, ACE-IQ Score and their interaction (familial risk*ACE-IQ score). The main effect of familial risk predicted poor performance in all domains of neurocognition (p < 0.01), and the interaction had negative association with global neurocognition (β = -0.093, p = 0.009), processing speed (β = -0.109, p = 0.003) and working memory (β = -0.092, p = 0.01). Among the ACEs sub-domains, only maltreatment, specifically the main effect of physical neglect, and interaction effect sexual abuse with familial risk predicted poorer neurocognition. In FDRs of schizophrenia and bipolar disorder, only the main effects of familial risk were significantly associated with neurocognition. We conclude that ACEs (especially maltreatment) are associated with neurocognition, but the relationship between childhood adversity and neurocognition is moderated by familial risk of mental illness. Genetic/familial vulnerability may have a stronger association with neurocognition in schizophrenia and bipolar disorder.<p />  <p>Language: en</p>
LA  - en
SN  - 0278-5846
UR  - http://dx.doi.org/10.1016/j.pnpbp.2022.110620
ID  - ref1
ER  -