TY  - JOUR
PY  - 2022//
TI  - The characterization of static and dynamic brain functional networks in suicide attempters with major depressive disorder and its relation to psychological pain
JO  - Psychiatry research. Neuroimaging
A1  - Hao, Ziyu
A1  - Li, Huanhuan
A1  - Lin, Yixuan
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Psychological pain is a robust predictor of suicide attempts in patients with major depressive disorder (MDD). However, whether suicide and psychological pain share a common neural basis remains unclear. Patients with MDD (n = 64) and healthy controls (HC) (n = 35) were recruited and patients were allocated to two groups: those with a history of suicide attempts (MDD-SA) (n = 25) and those without such a history (MDD-NSA) (n = 39). All participants completed the measurements and underwent functional magnetic resonance imaging to investigate the resting-state static and dynamic brain functional networks in default mode (DMN), central executive (CEN), salience (SN), and basal ganglia (BGN) networks. The MDD-SA group scored higher in pain avoidance than the MDD-NSA and HC groups. Functional connectivity within the dorsal DMN in the MDD-SA group was greater than that in the MDD-NSA and HC groups, and was significantly correlated with pain avoidance and suicide attempts. Dynamic functional connectivity analysis revealed that the proportion of State I in the fraction windows in the MDD-SA group was higher than those in the MDD-NSA and HC groups. Therefore, the increased functional connectivity within the dorsal DMN and segregation of networks may represent potential biological markers for suicide attempts related to psychological pain processing.<p />  <p>Language: en</p>
LA  - en
SN  - 0925-4927
UR  - http://dx.doi.org/10.1016/j.pscychresns.2022.111562
ID  - ref1
ER  -