TY - JOUR PY - 2022// TI - The efficacy of hemodialysis on paraquat poisoning mortality: a systematic review and meta-analysis JO - Journal of research in medical sciences A1 - Eizadi-Mood, Nastaran A1 - Jaberi, Danial A1 - Barouti, Zahra A1 - Rahimi, Alireza A1 - Mansourian, Marjan A1 - Dorooshi, Gholamali A1 - Sabzghabaee, Ali Mohammad A1 - Alfred, Sam SP - e74 EP - e74 VL - 27 IS - N2 - BACKGROUND: Paraquat (PQ) poisoning is a serious public health concern, especially in developing countries, due to its easy access and lack of awareness of potential harms. No effective treatment has been reported yet. Conventional hemodialysis (HD) is still used in many centers for excreting PQ or reducing acute kidney injury, but there is no consensus on its efficacy. Therefore, we aimed to review the HD efficacy in PQ poisoning mortality.

MATERIALS AND METHODS: We searched Web of Science, PubMed, Excerpta Medical Database, Google Scholar, Scopus, Cochrane, Web of Knowledge, Pro-Quest, ScienceDirect, Springer, Clinical Key, Scientific Information Database, Magiran, and Iran-doc, in publications before January 1, 2020. We compared patients who underwent HD (Group 1) with those who did not (Group 2). The outcome was considered mortality/survival. The data were analyzed by Comprehensive Meta-analysis Software.

RESULTS: This systematic review and meta-analysis included five studies with a combined total of 203 patients. The patients in the Group 1 had higher mortality than Group 2 (odds ratio, 2.84; 95% confidence interval: 1.22-6.64; P = 0.02). There was no evidence of publication bias (P value for Egger's test = 0.833).

CONCLUSION: Although HD did not affect the survival of patients, other variables such as the amount of ingested PQ, poisoning severity, the time between PQ ingestion and the start of HD, duration, and times of HD sessions may influence the results regarding mortality.

Language: en

LA - en SN - 1735-1995 UR - http://dx.doi.org/10.4103/jrms.jrms_235_21 ID - ref1 ER -