TY  - JOUR
PY  - 2022//
TI  - Dynamic predictors of in-hospital and 3-year mortality after traumatic brain injury: a retrospective cohort study
JO  - American journal of surgery
A1  - Wilson, Laura D.
A1  - Maiga, Amelia W.
A1  - Lombardo, Sarah
A1  - Nordness, Mina F.
A1  - Haddad, Diane N.
A1  - Rakhit, Shayan
A1  - Smith, Laney F.
A1  - Rivera, Erika L.
A1  - Cook, Madison R.
A1  - Thompson, Jennifer L.
A1  - Raman, Rameela
A1  - Patel, Mayur B.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Mortality risks after Traumatic Brain Injury (TBI) are understudied in critical illness. We sought to identify risks of mortality in critically ill patients with TBI using time-varying covariates. <br><br>METHODS: This single-center, six-year (2006-2012), retrospective cohort study measured demographics, injury characteristics, and daily data of acute TBI patients in the Intensive Care Unit (ICU). Time-varying Cox proportional hazards models assessed in-hospital and 3-year mortality. <br><br>RESULTS: Post-TBI ICU patients (n = 2664) experienced 20% in-hospital mortality (n = 529) and 27% (n = 706) 3-year mortality. Glasgow Coma Scale motor subscore (hazard ratio (HR) 0.58, p < 0.001), pupil reactivity (HR 3.17, p < 0.001), minimum glucose (HR 1.44, p < 0.001), mSOFA score (HR 1.81, p < 0.001), coma (HR 2.26, p < 0.001), and benzodiazepines (HR 1.38, p < 0.001) were associated with in-hospital mortality. At three years, public insurance (HR 1.78, p = 0.011) and discharge disposition (HR 4.48, p < 0.001) were associated with death. <br><br>CONCLUSIONS: Time-varying characteristics influenced in-hospital mortality post-TBI. Socioeconomic factors primarily affect three-year mortality.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-9610
UR  - http://dx.doi.org/10.1016/j.amjsurg.2022.10.003
ID  - ref1
ER  -